Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Hematology (2024)
- Medical Education: Stanford University School of Medicine (1995) CA
- Fellowship: Stanford University Hematology and Oncology Fellowship (2003) CA
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- Residency: Stanford University Internal Medicine Residency (1998) CA
- Internship: Stanford University Internal Medicine Residency (1996) CA
- B.A., Franklin & Marshall College, Biology; HAPOS (1990)
- M.D., Stanford, Medicine (1995)
- M.S., Stanford, Clinical Epidemiology (2003)
Honors & Awards
- Charles Dorsey Armstrong Award for Excellence in Patient Care, Stanford Internal Medicine Residency Program (1998)
- Hematology Division Faculty Teaching Award, Stanford Division of Hematology/Department of Medicine (2005, 2007, 2009)
- NIH K23 Mentored Patient-Oriented Research Career Development Award (#HL04409), National Institutes of Health (2001-2006)
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Publications
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Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate
Coutre, S., & Gotlib, J. (2004). Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate. SEMINARS IN CANCER BIOLOGY, 14(1), 23鈥31. -
The HP1L1-PDIGFR alpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
Gotlib, J., Cools, J., Malone, J. M., Schrier, S. L., Gilliland, D. G., & Coutre, S. E. (2004). The HP1L1-PDIGFR alpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management. BLOOD, 103(8), 2879鈥91. -
Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate.
Coutr茅, S., & Gotlib, J. (2004). Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate. Seminars in Cancer Biology, 14(4), 307鈥15. -
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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., 鈥 Weissman, I. L. (2004). Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. NEW ENGLAND JOURNAL OF MEDICINE, 351(7), 657鈥67. -
Farnesyltransferase inhibitor therapy in acute myelogenous leukemia.
Gotlib, J. (2005). Farnesyltransferase inhibitor therapy in acute myelogenous leukemia. Current Hematology Reports, 4(1), 77鈥84. -
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
Gotlib, J., Berube, C., Growney, J. D., Chen, C. C., George, T. I., Williams, C., 鈥 Coutre, S. E. (2005). Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. BLOOD, 106(8), 2865鈥70. -
Molecular classification and pathogenesis of eosinophilic disorders: 2005 update
Gotlib, J. (2005). Molecular classification and pathogenesis of eosinophilic disorders: 2005 update. ACTA HAEMATOLOGICA, 114(1), 7鈥25. -
Eosinophilic disorders: Molecular pathogenesis, new classification, and modern therapy
Gotlib, J., Cross, N. C. R., & Gilliland, D. G. (2006). Eosinophilic disorders: Molecular pathogenesis, new classification, and modern therapy. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 19(3), 535鈥569. -
Detection of the JAK2 V617F mutation by LightCycler PCR and probe dissociation analysis
Lay, M., Mariappan, R., Gotlib, J., Dietz, L., Sebastian, S., Schrijver, I., & Zehnder, J. L. (2006). Detection of the JAK2 V617F mutation by LightCycler PCR and probe dissociation analysis. JOURNAL OF MOLECULAR DIAGNOSTICS, 8(3), 330鈥34. -
A patient with paroxysmal nocturnal hemoglobinuria, T cell large granular lymphocyte clonal expansion, and monoclonal gammopathy of undetermined significance
Fukumoto, J. S., & Gotlib, J. (2006). A patient with paroxysmal nocturnal hemoglobinuria, T cell large granular lymphocyte clonal expansion, and monoclonal gammopathy of undetermined significance. AMERICAN JOURNAL OF HEMATOLOGY, 81(11), 870鈥74. -
KIT mutations in mastocytosis and their potential as therapeutic targets
Gotlib, J. (2006). KIT mutations in mastocytosis and their potential as therapeutic targets. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 26(3), 575-? -
Use of urine flow cytometry to verify relapse of Burkitt's lymphoma in the genitourinary system
Dormady, S. P., Mariappan, M. R., Kao, D., & Gotlib, J. (2006). Use of urine flow cytometry to verify relapse of Burkitt's lymphoma in the genitourinary system. JOURNAL OF CLINICAL ONCOLOGY, 24(27), 4515鈥16. -
Gene expression and pathway analysis of immune thrombocytopenic purpura
Sood, R., Wong, W., Gotlib, J., Jeng, M., & Zehnder, J. L. (2008). Gene expression and pathway analysis of immune thrombocytopenic purpura. BRITISH JOURNAL OF HAEMATOLOGY, 140(1), 99鈥103. -
Chronic eosinophilic leukemia/hypereosinophilic syndrome.
Gotlib, J. (2008). Chronic eosinophilic leukemia/hypereosinophilic syndrome. Cancer Treatment and Research, 142, 69鈥106. -
Selective inhibition of JAK2-Driven erythroid differentiation of polycythemia vera progenitors
Geron, I., Abrahamsson, A. E., Barroga, C. F., Kavalerchik, E., Gotlib, J., Hood, J. D., 鈥 Jamieson, C. H. M. (2008). Selective inhibition of JAK2-Driven erythroid differentiation of polycythemia vera progenitors. CANCER CELL, 13(4), 321鈥330. -
Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias
Gotlib, J., & Cools, J. (2008). Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias. LEUKEMIA, 22(11), 1999鈥2010. -
A phase II intra-patient dose-escalation trial of weight-based darbepoetin alfa with or without granulocyte-colony stimulating factor in myelodysplastic syndromes
Gotlib, J., Lavori, P., Quesada, S., Stein, R. S., Shahnia, S., & Greenberg, P. L. (2009). A phase II intra-patient dose-escalation trial of weight-based darbepoetin alfa with or without granulocyte-colony stimulating factor in myelodysplastic syndromes. AMERICAN JOURNAL OF HEMATOLOGY, 84(1), 15鈥20. -
Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system
Weinberg, O. K., Seetharam, M., Ren, L., Seo, K., Ma, L., Merker, J. D., 鈥 Arber, D. A. (2009). Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system. BLOOD, 113(9), 1906鈥8. -
Glycogen synthase kinase 3 beta missplicing contributes to leukemia stem cell generation
Abrahamsson, A. E., Geron, I., Gotlib, J., Dao, K.-H. T., Barroga, C. F., Newton, I. G., 鈥 Jamieson, C. H. M. (2009). Glycogen synthase kinase 3 beta missplicing contributes to leukemia stem cell generation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(10), 3925鈥29. -
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens
Fan, A. C., Deb-Basu, D., Orban, M. W., Gotlib, J. R., Natkunam, Y., O'Neill, R., 鈥 Felsher, D. W. (2009). Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens. NATURE MEDICINE, 15(5), 566鈥71. -
RNAi screen for rapid therapeutic target identification in leukemia patients
Tyner, J. W., Deininger, M. W., Loriaux, M. M., Chang, B. H., Gotlib, J. R., Willis, S. G., 鈥 Druker, B. J. (2009). RNAi screen for rapid therapeutic target identification in leukemia patients. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(21), 8695鈥8700. -
Monoclonal antibodies against IREM-1: potential for targeted therapy of AML
Korver, W., Zhao, X., Singh, S., Pardoux, C., Zhao, J., Guzman, M. L., 鈥 Abo, A. (2009). Monoclonal antibodies against IREM-1: potential for targeted therapy of AML. LEUKEMIA, 23(9), 1587鈥97. -
Molecular stratification of patients with normal karyotype acute myeloid leukemia based on initial assessment of FLT3-internal tandem duplication status at first complete remission
Medeiros, B. C., Gotlib, J., & Zehnder, J. (2009). Molecular stratification of patients with normal karyotype acute myeloid leukemia based on initial assessment of FLT3-internal tandem duplication status at first complete remission. LEUKEMIA & LYMPHOMA, 50(5), 851鈥53. -
Novel biospecific agents for the treatment of myelodysplastic syndromes.
Gotlib, J., & Greenberg, P. L. (2003). Novel biospecific agents for the treatment of myelodysplastic syndromes. Journal of the National Comprehensive Cancer Network , 1(4), 473鈥80. -
When yellow jackets attack: recurrent and severe anaphylactic reactions to insect bites and stings
Pollyea, D. A., George, T. I., Corless, C., & Gotlib, J. (2009). When yellow jackets attack: recurrent and severe anaphylactic reactions to insect bites and stings. AMERICAN JOURNAL OF HEMATOLOGY, 84(12), 843鈥46. -
On being metachromatic: mystique and misunderstanding in mastocytosis
Gotlib, J. (2009). On being metachromatic: mystique and misunderstanding in mastocytosis. AMERICAN JOURNAL OF HEMATOLOGY, 84(12), 779鈥81. -
Design and Evaluation of a Real-Time PCR Assay for Quantification of JAK2 V617F and Wild-Type JAK2 Transcript Levels in the Clinical Laboratory
Merker, J. D., Jones, C. D., Oh, S. T., Schrijver, I., Gotlib, J., & Zehnder, J. L. (2010). Design and Evaluation of a Real-Time PCR Assay for Quantification of JAK2 V617F and Wild-Type JAK2 Transcript Levels in the Clinical Laboratory. JOURNAL OF MOLECULAR DIAGNOSTICS, 12(1), 58鈥64. -
Eosinophilic myeloid disorders: new classification and novel therapeutic strategies
Gotlib, J. (2010). Eosinophilic myeloid disorders: new classification and novel therapeutic strategies. CURRENT OPINION IN HEMATOLOGY, 17(2), 117鈥24. -
Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms
Hidalgo-Curtis, C., Apperley, J. F., Stark, A., Jeng, M., Gotlib, J., Chase, A., 鈥 Grand, F. H. (2010). Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms. BRITISH JOURNAL OF HAEMATOLOGY, 148(2), 268鈥73. -
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
Oh, S. T., Simonds, E. F., Jones, C., Hale, M. B., Goltsev, Y., Gibbs, K. D., 鈥 Gotlib, J. (2010). Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. BLOOD, 116(6), 988鈥92. -
Antiangiogenic therapy in myelodysplastic syndromes: is there a role?
Oh, S. T., & Gotlib, J. (2008). Antiangiogenic therapy in myelodysplastic syndromes: is there a role? Current Hematologic Malignancy Reports, 3(1), 10鈥18. -
Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: A diagnostic challenge
Arredondo, A. R., Gotlib, J., Shier, L., Medeiros, B., Wong, K., Cherry, A., 鈥 George, T. I. (2010). Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: A diagnostic challenge. AMERICAN JOURNAL OF HEMATOLOGY, 85(8), 600鈥606. -
Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: A single-center experience
Kohrt, H. E., Patel, S., Ho, M., Owen, T., Pollyea, D. A., Majeti, R., 鈥 Medeiros, B. C. (2010). Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: A single-center experience. AMERICAN JOURNAL OF HEMATOLOGY, 85(11), 877鈥81. -
JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms
Oh, S. T., & Gotlib, J. (2010). JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms. EXPERT REVIEW OF HEMATOLOGY, 3(3), 323鈥37. -
Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis
Pardanani, A., Gotlib, J. R., Jamieson, C., Cortes, J. E., Talpaz, M., Stone, R. M., 鈥 Tefferi, A. (2011). Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis. JOURNAL OF CLINICAL ONCOLOGY, 29(7), 789鈥796. -
World Health Organization-defined eosinophilic disorders: 2011 update on diagnosis, risk stratification, and management.
Gotlib, J. (2011). World Health Organization-defined eosinophilic disorders: 2011 update on diagnosis, risk stratification, and management. American Journal of Hematology, 86(8), 677鈥88. -
Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors
Pollyea, D. A., Raval, A., Kusler, B., Gotlib, J. R., Alizadeh, A. A., & Mitchell, B. S. (2011). Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. HEMATOLOGICAL ONCOLOGY, 29(3), 157鈥60. -
Treatment advances have not improved the early death rate in acute promyelocytic leukemia
McClellan, J. S., Kohrt, H. E., Coutre, S., Gotlib, J. R., Majeti, R., Alizadeh, A. A., & Medeiros, B. C. (2012). Treatment advances have not improved the early death rate in acute promyelocytic leukemia. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 97(1), 133鈥36. -
Phase I trial of a novel human monoclonal antibody mAb216 in patients with relapsed or refractory B-cell acute lymphoblastic leukemia
Liedtke, M., Twist, C. J., Medeiros, B. C., Gotlib, J. R., Berube, C., Bieber, M. M., 鈥 Coutre, S. E. (2012). Phase I trial of a novel human monoclonal antibody mAb216 in patients with relapsed or refractory B-cell acute lymphoblastic leukemia. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 97(1), 30鈥37. -
Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia
Pollyea, D. A., Kohrt, H. E., Gallegos, L., Figueroa, M. E., Abdel-Wahab, O., Zhang, B., 鈥 Medeiros, B. C. (2012). Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. LEUKEMIA, 26(5), 893鈥901. -
Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia
Medeiros, B. C., Kohrt, H. E., Gotlib, J., Coutre, S. E., Zhang, B., Arber, D. A., & Zehnder, J. L. (2012). Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia. AMERICAN JOURNAL OF HEMATOLOGY, 87(1), 45鈥50. -
A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia.
Zhang, B., Ng, D., Jones, C., Oh, S. T., Nolan, G. P., Salehi, S., 鈥 Gotlib, J. (2011). A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia. Blood, 118(26), 6988鈥90. -
Mast Cells and Eosinophils in Mastocytosis, Chronic Eosinophilic Leukemia, and Non-clonal Disorders
Gotlib, J., & Akin, C. (2012). Mast Cells and Eosinophils in Mastocytosis, Chronic Eosinophilic Leukemia, and Non-clonal Disorders. SEMINARS IN HEMATOLOGY, 49(2), 128鈥37. -
DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groups
Ohgami, R. S., Ma, L., Ren, L., Weinberg, O. K., Seetharam, M., Gotlib, J. R., & Arber, D. A. (2012). DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groups. BRITISH JOURNAL OF HAEMATOLOGY, 159(2), 182鈥90. -
World Health Organization-defined eosinophilic disorders: 2012 update on diagnosis, risk stratification, and management.
Gotlib, J. (2012). World Health Organization-defined eosinophilic disorders: 2012 update on diagnosis, risk stratification, and management. American Journal of Hematology, 87(9), 903鈥14. -
Accessory splenules in autoimmune hemolytic anemia.
Logan, A., Berube, C., & Gotlib, J. (2013). Accessory splenules in autoimmune hemolytic anemia. American Journal of Hematology, 88(2), 156-? -
Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia.
Pollyea, D. A., Zehnder, J., Coutre, S., Gotlib, J. R., Gallegos, L., Abdel-Wahab, O., 鈥 Medeiros, B. C. (2013). Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. Haematologica, 98(4), 591鈥96. -
ICON: Eosinophil Disorders.
Valent, P., Klion, A. D., Rosenwasser, L. J., Arock, M., Bochner, B. S., Butterfield, J. H., 鈥 Gleich, G. J. (2012). ICON: Eosinophil Disorders. The World Allergy Organization Journal, 5(12), 174鈥81. -
International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis
Gotlib, J., Pardanani, A., Akin, C., Reiter, A., George, T., Hermine, O., 鈥 Valent, P. (2013). International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis. BLOOD, 121(13), 2393鈥2401. -
Effect of Ruxolitinib Therapy on Myelofibrosis-Related Symptoms and Other Patient-Reported Outcomes in COMFORT-I: A Randomized, Double-Blind, Placebo-Controlled Trial
Mesa, R. A., Gotlib, J., Gupta, V., Catalano, J. V., Deininger, M. W., Shields, A. L., 鈥 Verstovsek, S. (2013). Effect of Ruxolitinib Therapy on Myelofibrosis-Related Symptoms and Other Patient-Reported Outcomes in COMFORT-I: A Randomized, Double-Blind, Placebo-Controlled Trial. JOURNAL OF CLINICAL ONCOLOGY, 31(10), 1285鈥1292. -
Next-generation sequencing in hematologic malignancies: what will be the dividends?
Merker, J. D., Valouev, A., & Gotlib, J. (2012). Next-generation sequencing in hematologic malignancies: what will be the dividends? Therapeutic Advances in Hematology, 3(6), 333鈥39. -
SAR302503: Interim Safety, Efficacy and Long-Term Impact on JAK2 V617F Allele Burden in a Phase I/II Study in Patients with Myelofibrosis
Pardanani, A., Gotlib, J., Jamieson, C., Cortes, J. E., Talpaz, M., Stone, R., 鈥 Tefferi, A. (2011). SAR302503: Interim Safety, Efficacy and Long-Term Impact on JAK2 V617F Allele Burden in a Phase I/II Study in Patients with Myelofibrosis. BLOOD, 118(21), 1640鈥1640. -
Missplicing of glycogen synthase kinase 3 beta: A potential mechanism of blast crisis chronic myeloid leukemia stem cell generation
Abrahamsson, A., Geron, I., Gotlib, J., Dao, K.-H., Giles, F., Newton, I., 鈥 Jamieson, C. H. M. (2007). Missplicing of glycogen synthase kinase 3 beta: A potential mechanism of blast crisis chronic myeloid leukemia stem cell generation. BLOOD, 110(11), 238A鈥239A. -
NPM1 Haploinsufficiency Results in Increased Numbers of Hematopoietic Stem Cells and Progenitor Cells
Raval, A., Park, C. Y., Pang, W. W., Kusler, B., Sridhar, K. J., Gotlib, J. R., 鈥 Mitchell, B. S. (2009). NPM1 Haploinsufficiency Results in Increased Numbers of Hematopoietic Stem Cells and Progenitor Cells. BLOOD, 114(22), 307鈥. -
Myelomastocytic Leukemia: A Clinical, Pathologic, and Molecular Genetic Study
McGuire, A., Shier, L. R., Gotlib, J., Medeiros, B., Wong, K., Corless, C., 鈥 George, T. I. (2009). Myelomastocytic Leukemia: A Clinical, Pathologic, and Molecular Genetic Study. Presented at the 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, BOSTON,MA: NATURE PUBLISHING GROUP. -
Consistent Benefit of Ruxolitinib Over Placebo in Spleen Volume Reduction and Symptom Improvement Across Subgroups and Overall Survival Advantage: Results From COMFORT-I
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. M. (2011). Consistent Benefit of Ruxolitinib Over Placebo in Spleen Volume Reduction and Symptom Improvement Across Subgroups and Overall Survival Advantage: Results From COMFORT-I. BLOOD, 118(21), 128鈥129. -
Whole Genome Sequence Analysis of Primary Myelofibrosis.
Merker, J. D., Roskin, K., Ng, D., Pan, C., Fisk, D. G., Jones, C. D., 鈥 Gotlib, J. (2012). Whole Genome Sequence Analysis of Primary Myelofibrosis. BLOOD. ATLANTA,GA,GA,GA,GA,GA,GA,GA,GA: AMER SOC HEMATOLOGY. -
Amrubicin, a Novel Investigational Anthracycline, in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Results of a Phase 1 Dose-Escalation Study
Dinner, S. N., Dunn, T. J., Medeiros, B. C., Coutre, S. E., Berube, C., Gotlib, J., & Liedtke, M. (2012). Amrubicin, a Novel Investigational Anthracycline, in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Results of a Phase 1 Dose-Escalation Study. BLOOD, 120(21). -
A Phase I/II Study of Bortezomib (VELCADE) in Combination with Pralatrexate in Relapsed/Refractory Multiple Myeloma
Dunn, T. J., Dinner, S. N., Berube, C., Gotlib, J., Coutre, S. E., Medeiros, B. C., & Liedtke, M. (2012). A Phase I/II Study of Bortezomib (VELCADE) in Combination with Pralatrexate in Relapsed/Refractory Multiple Myeloma. BLOOD, 120(21). -
Temozolomide In Acute Myeloid Leukemia: A MGMT Promoter Methylation Status-Based Treatment Stratification
Medeiros, B. C., Kohrt, H. E., Rajwanshi, R., Gotlib, J., Coutre, S., Liedtke, M., 鈥 Zehnder, J. L. (2010). Temozolomide In Acute Myeloid Leukemia: A MGMT Promoter Methylation Status-Based Treatment Stratification. BLOOD, 116(21), 1357鈥58. -
A Phase I Study of Sequential Azacitidine and Lenalidomide for Elderly Patients with Acute Myeloid Leukemia (AML)
Pollyea, D. A., Kohrt, H. E., Gallegos, L., Berube, C., Coutre, S., Gotlib, J., 鈥 Medeiros, B. C. (2010). A Phase I Study of Sequential Azacitidine and Lenalidomide for Elderly Patients with Acute Myeloid Leukemia (AML). BLOOD, 116(21), 1347鈥47. -
Gene expression profile of idiopathic thrombocytopenic purpura (ITP) reveals elevated expression of interferon regulated genes.
Sood, R., Wong, W., Gotlib, J., Jeng, M., & Zehnder, J. L. (2006). Gene expression profile of idiopathic thrombocytopenic purpura (ITP) reveals elevated expression of interferon regulated genes. BLOOD, 108(11), 211A鈥211A. -
Identification of a Novel Splice Donor Mutation In the Thrombopoietin Gene In a Philippine Family with Hereditary Thrombocythemia
Gotlib, J., Zhang, B., Jones, C. D., Riess, J., Wong, W. B., Simonds, E. F., 鈥 Zehnder, J. L. (2010). Identification of a Novel Splice Donor Mutation In the Thrombopoietin Gene In a Philippine Family with Hereditary Thrombocythemia. BLOOD. ORLANDO,FL,FL,FL,FL,FL,FL,FL,FL: AMER SOC HEMATOLOGY. -
A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia
Ng, D., Jones, C., Oh, S. T., Nolan, G. P., Salehi, S., Wong, W., 鈥 Gotlib, J. (2011). A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia. BLOOD, 118(26), 6988-? -
Loss of CD25 Expression in Advanced Systemic Mastocytosis Patients Treated with Midostaurin (PKC412)
Kunder, C. A., DeAngelo, D. J., Gotlib, J. R., Gitana, G., Atwater, S. K., & George, T. I. (2012). Loss of CD25 Expression in Advanced Systemic Mastocytosis Patients Treated with Midostaurin (PKC412). Presented at the 101st Annual Meeting of United-States-and-Canadian-Academy-of-Pathology (USCAP), VANCOUVER,CANADA,CANADA: NATURE PUBLISHING GROUP. -
Acute Myeloid Leukemia with Myelodysplasia-Related Changes as Defined by the 2008 WHO Classification System
Weinberg, O. K., Seetharam, M., Ren, L., Ma, L., Seo, K., Merker, J., 鈥 Arber, D. A. (2009). Acute Myeloid Leukemia with Myelodysplasia-Related Changes as Defined by the 2008 WHO Classification System. Presented at the 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, BOSTON,MA,MA,MA,MA: NATURE PUBLISHING GROUP. -
Significance of NPM1 and FLT3 mutations in acute myeloid leukemia with multilineage dysplasia: Does NPM1 identify a lower risk group?
Weinberg, O., Merker, J., Beck, A., Seetharam, M., Gotlib, J., Zehnder, J., & Arber, D. A. (2008). Significance of NPM1 and FLT3 mutations in acute myeloid leukemia with multilineage dysplasia: Does NPM1 identify a lower risk group? Presented at the 97th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, DENVER,CO,CO,CO,CO: NATURE PUBLISHING GROUP. -
Clinical Characterization of Acute Myeloid Leukemia with Myelodysplasia-Related Changes as Defined by the 2008 WHO Classification System
Weinberg, O. K., Seetharam, M., Ren, L., Ma, L., Seo, K., Merker, J. D., 鈥 Arber, D. A. (2008). Clinical Characterization of Acute Myeloid Leukemia with Myelodysplasia-Related Changes as Defined by the 2008 WHO Classification System. BLOOD, 112(11), 341鈥42. -
Design and Validation of a Real-Time PCR Assay for Quantification of JAK2 V617F and Wild-type JAK2 Transcript Levels
Merker, J. D., Jones, C. D., Oh, S. T., Khan, S., Schrijver, I., Gotlib, J., & Zehnder, J. L. (2008). Design and Validation of a Real-Time PCR Assay for Quantification of JAK2 V617F and Wild-type JAK2 Transcript Levels. JOURNAL OF MOLECULAR DIAGNOSTICS, 10(6), 581鈥81. -
Early Mortality in Acute Promyelocytic Leukemia May Be Higher Than Previously Reported.
Alizadeh, A. A., McClellan, J. S., Gotlib, J. R., Coutre, S., Majeti, R., Kohrt, H. E., & Medeiros, B. C. (2009). Early Mortality in Acute Promyelocytic Leukemia May Be Higher Than Previously Reported. BLOOD, 114(22), 420鈥21. -
Identification of Novel LNK Mutations In Patients with Chronic Myeloproliferative Neoplasms and Related Disorders
Oh, S. T., Zahn, J. M., Jones, C. D., Zhang, B., Loh, M. L., Kantarjian, H., 鈥 Gotlib, J. (2010). Identification of Novel LNK Mutations In Patients with Chronic Myeloproliferative Neoplasms and Related Disorders. BLOOD. ORLANDO,FL,FL,FL,FL,FL,FL,FL,FL: AMER SOC HEMATOLOGY. -
Correlation of Symptom Assessment with Genotyping Analysis of Saliva Samples in a Large Cohort of Myeloproliferative Neoplasm Patients
Nguyen, H. (M., Hinds, D. A., Barnholt, K. E., Kiefer, A. K., Do, C. B., Eriksson, N., 鈥 Mesa, R. A. (2012). Correlation of Symptom Assessment with Genotyping Analysis of Saliva Samples in a Large Cohort of Myeloproliferative Neoplasm Patients. BLOOD. ATLANTA,GA,GA,GA,GA,GA: AMER SOC HEMATOLOGY. -
FDA-Approved Ruxolitinib in Patients with Myelofibrosis: the Stanford Experience
Nguyen, H. (M., Anh Pham, A., Perkins, C., Linder, A., Fechter, L., & Gotlib, J. (2012). FDA-Approved Ruxolitinib in Patients with Myelofibrosis: the Stanford Experience. BLOOD, 120(21). -
Estimation of JAK2 V617F Prevalence by Detection of the Mutation in Saliva Samples From Online MPN and General Population Cohorts
Barnholt, K. E., Hinds, D. A., Kiefer, A. K., Do, C. B., Eriksson, N., Mountain, J. L., 鈥 Zehnder, J. L. (2012). Estimation of JAK2 V617F Prevalence by Detection of the Mutation in Saliva Samples From Online MPN and General Population Cohorts. BLOOD. ATLANTA,GA,GA,GA,GA,GA: AMER SOC HEMATOLOGY. -
BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor
Goff, D., Smith, K. M., Shih, A. Y., Court-Recart, A., Sadarangani, A., Geron, I., 鈥 Jamieson, C. (2011). BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor. BLOOD, 118(21), 1176鈥76. -
Inhibition of chronic myelogenous leukemia stem cells with novel wnt antagonists.
Kavalerchik, E., Gotlib, J., Geron, I., Abrahamsson, A., Wrasidlo, W., Goff, D., 鈥 Jamieson, C. (2006). Inhibition of chronic myelogenous leukemia stem cells with novel wnt antagonists. BLOOD, 108(11), 74A鈥75A. -
A Detailed Flow Cytometry Analysis of the Immune System in Non-Leukemic Cells of Acute Myeloid Leukemia Demonstrates the Prognostic Significance of Lymphocyte Subsets
Ohgami, R. S., Alcasid, M., Ren, L., Gotlib, J. R., & Arber, D. A. (2013). A Detailed Flow Cytometry Analysis of the Immune System in Non-Leukemic Cells of Acute Myeloid Leukemia Demonstrates the Prognostic Significance of Lymphocyte Subsets. Presented at the 102nd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), BALTIMORE,MD: NATURE PUBLISHING GROUP. -
Hypereosinophilic Syndrome and Clonal Eosinophilia: Point-of-Care Diagnostic Algorithm and Treatment Update
Tefferi, A., Gotlib, J., & Pardanani, A. (2010). Hypereosinophilic Syndrome and Clonal Eosinophilia: Point-of-Care Diagnostic Algorithm and Treatment Update. MAYO CLINIC PROCEEDINGS, 85(2), 158鈥164. -
Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML
Maxson, J. E., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., 鈥 Tyner, J. W. (2013). Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML. NEW ENGLAND JOURNAL OF MEDICINE, 368(19), 1781鈥90. -
PTPN11 mutations are rare in adult patients with chronic myelomonocytic leukemia (CMML).
Loh, M. L., Vattikuti, S., Reynolds, M. G., Cheng, J. W., Lee, C. M., Gotlib, J., & Beran, M. (2003). PTPN11 mutations are rare in adult patients with chronic myelomonocytic leukemia (CMML). BLOOD, 102(11), 328B鈥328B. -
Inhibition of JAK2 V617F-Induced erythroid skewing of hematopoietic stem cell differentiation with a selective JAK2 antagonist.
Geron, I., Barroga, C., Gotlib, J., Kavalerchik, E., Abrahamsson, A., Goff, D., 鈥 Jamieson, C. (2006). Inhibition of JAK2 V617F-Induced erythroid skewing of hematopoietic stem cell differentiation with a selective JAK2 antagonist. BLOOD, 108(11), 1033A鈥1033A. -
Aberrant regulation of Wnt/beta-catenin pathway mediators in chronic myelogenous leukemia stem cells
Abrahamsson, A., Geron, I., Gotlib, J., Durocher, J., Creusot, R., Kavalerchik, E., 鈥 Jamieson, C. (2006). Aberrant regulation of Wnt/beta-catenin pathway mediators in chronic myelogenous leukemia stem cells. BLOOD, 108(11), 605A鈥605A. -
Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib
Leu, H. S., Goff, D. J., Low-Marchelli, J., Recart, A. C. C., Smith, K. M., Ma, W., 鈥 Jamieson, C. (2012). Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib. BLOOD, 120(21). -
Interim results of protracted low doses of temozolomide in high-risk acute myeloid leukemia
Medeiros, B. C., Gotlib, J. R., Coutre, S. E., Jones, C., Khan, S. A., Rajwanshi, R., 鈥 Zehnder, J. (2009). Interim results of protracted low doses of temozolomide in high-risk acute myeloid leukemia. JOURNAL OF CLINICAL ONCOLOGY, 27(15). -
Is Time of the Essence in Adult Acute Myeloid Leukemia (AML)? Time to Blast Clearance and Time to Induction Therapy Fail to Predict Overall Survival (OS).
Kohrt, H. E., Patel, S., Ho, M., Owen, T., Majeti, R., Gotlib, J. R., 鈥 Alizadeh, A. A. (2009). Is Time of the Essence in Adult Acute Myeloid Leukemia (AML)? Time to Blast Clearance and Time to Induction Therapy Fail to Predict Overall Survival (OS). BLOOD, 114(22), 646鈥47. -
The KIT tyrosine kinase inhibitor midostaurine (PKC412) exhibits a high response rate in aggressive systemic mastocytosis (ASM): Interim results of a phase II trial
Gotlib, J., George, T. I., Corless, C., Linder, A., Ruddell, A., Akin, C., 鈥 Graubert, T. (2007). The KIT tyrosine kinase inhibitor midostaurine (PKC412) exhibits a high response rate in aggressive systemic mastocytosis (ASM): Interim results of a phase II trial. BLOOD, 110(11), 1035A鈥1035A. -
Chronic Myelogenous Leukemia
O'Brien, S., Abboud, C. N., Akhtari, M., Altman, J., Berman, E., DeAngelo, D. J., 鈥 Yunus, F. (2012). Chronic Myelogenous Leukemia. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 10(1), 64鈥110. -
A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
Lancet, J. E., Gojo, I., Gotlib, J., Feldman, E. J., Greer, J., Liesveld, J. L., 鈥 Karp, J. E. (2007). A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. BLOOD, 109(4), 1387鈥94. -
Chronic Myelogenous Leukemia
O'Brien, S., Berman, E., Borghaei, H., DeAngelo, D. J., Devetten, M. P., Devine, S., 鈥 Wetzler, M. (2009). Chronic Myelogenous Leukemia. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 7(9), 984鈥1023. -
World Health Organization-defined eosinophilic disorders: 2011 update on diagnosis, risk stratification, and management
Gotlib, J. (2011). World Health Organization-defined eosinophilic disorders: 2011 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY, 86(8), 678鈥88. -
The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment.
Gotlib, J., Maxson, J. E., George, T. I., & Tyner, J. W. (2013). The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment. Blood, 122(10), 1707鈥11. -
Editorial.
Gotlib, J. (2013). Editorial. Therapeutic Advances in Hematology, 4(4), 235鈥236. -
Hidden Mastocytosis in Acute Myeloid Leukemia With t(8;21)(q22;q22).
Johnson, R. C., Savage, N. M., Chiang, T., Gotlib, J. R., Cherry, A. M., Arber, D. A., & George, T. I. (2013). Hidden Mastocytosis in Acute Myeloid Leukemia With t(8;21)(q22;q22). American Journal of Clinical Pathology, 140(4), 525鈥35. -
Comprehensive whole-genome sequencing of an early-stage primary myelofibrosis patient defines low mutational burden and non-recurrent candidate genes.
Merker, J. D., Roskin, K. M., Ng, D., Pan, C., Fisk, D. G., King, J. J., 鈥 Gotlib, J. (2013). Comprehensive whole-genome sequencing of an early-stage primary myelofibrosis patient defines low mutational burden and non-recurrent candidate genes. Haematologica, 98(11), 1689鈥96. -
A 2-gene classifier for predicting response to the famesyltransferase inhibitor tipifarnib in acute myeloid leukemia
Raponi, M., Lancet, J. E., Fan, H., Dossey, L., Lee, G., Gojo, I., 鈥 Karp, J. E. (2008). A 2-gene classifier for predicting response to the famesyltransferase inhibitor tipifarnib in acute myeloid leukemia. BLOOD, 111(5), 2589鈥96. -
Chronic Myelogenous Leukemia, Version 1.2014 Featured Updates to the NCCN Guidelines
O'Brien, S., Radich, J. P., Abboud, C. N., Akhtari, M., Altman, J. K., Berman, E., 鈥 Sundar, H. (2013). Chronic Myelogenous Leukemia, Version 1.2014 Featured Updates to the NCCN Guidelines. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 11(11), 1327鈥40. -
A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition
Goff, D. J., Recart, A. C., Sadarangani, A., Chun, H.-J., Barrett, C. L., Krajewska, M., 鈥 Jamieson, C. H. M. (2013). A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition. CELL STEM CELL, 12(3), 316鈥28. -
Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field
Valent, P., Gleich, G. J., Reiter, A., Roufosse, F., Weller, P. F., Hellmann, A., 鈥 Klion, A. D. (2012). Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field. EXPERT REVIEW OF HEMATOLOGY, 5(2), 157鈥76. -
Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes
Valent, P., Klion, A. D., Horny, H.-P., Roufosse, F., Gotlib, J., Weller, P. F., 鈥 Gleich, G. J. (2012). Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 130(3), 607-? -
Acute myeloid leukemia with monosomal karyotype: morphologic, immunophenotypic, and molecular findings.
Weinberg, O. K., Ohgami, R. S., Ma, L., Seo, K., Ren, L., Gotlib, J. R., 鈥 Arber, D. A. (2014). Acute myeloid leukemia with monosomal karyotype: morphologic, immunophenotypic, and molecular findings. American Journal of Clinical Pathology, 142(2), 190鈥95. -
Intensive serial biomarker profiling for the prediction of neutropenic Fever in patients with hematologic malignancies undergoing chemotherapy: a pilot study.
Chan, S. M., Chadwick, J., Young, D. L., Holmes, E., & Gotlib, J. (2014). Intensive serial biomarker profiling for the prediction of neutropenic Fever in patients with hematologic malignancies undergoing chemotherapy: a pilot study. Hematology Reports, 6(2), 5466-? -
Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: Proceedings from the 5th International Post-ASH Symposium
Tefferi, A., Abdel-Wahab, O., Cervantes, F., Crispino, J. D., Finazzi, G., Girodon, F., 鈥 Mughal, T. (2011). Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: Proceedings from the 5th International Post-ASH Symposium. BLOOD CANCER JOURNAL, 1. -
The serum tryptase test: an emerging robust biomarker in clinical hematology
Valent, P., Sperr, W. R., Sotlar, K., Reiter, A., Akin, C., Gotlib, J., 鈥 Arock, M. (2014). The serum tryptase test: an emerging robust biomarker in clinical hematology. EXPERT REVIEW OF HEMATOLOGY, 7(5), 683鈥90. -
Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal
Valent, P., Sotlar, K., Sperr, W. R., Escribano, L., Yavuz, S., Reiter, A., 鈥 Horny, H.-P. (2014). Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal. ANNALS OF ONCOLOGY, 25(9), 1691鈥1700. -
Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis
Valent, P., Escribano, L., Broesby-Olsen, S., Hartmann, K., Grattan, C., Brockow, K., 鈥 Arock, M. (2014). Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis. ALLERGY, 69(10), 1267鈥74. -
Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations
Ohgami, R. S., Ma, L., Merker, J. D., Gotlib, J. R., Schrijver, I., Zehnder, J. L., & Arber, D. A. (2015). Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations. MODERN PATHOLOGY, 28(5), 706鈥14. -
Salvage therapy with mitoxantrone, etoposide and cytarabine in relapsed or refractory acute lymphoblastic leukemia
Liedtke, M., Dunn, T., Dinner, S., Coutre, S. E., Berubea, C., Gotlib, J., 鈥 Medeiros, B. (2014). Salvage therapy with mitoxantrone, etoposide and cytarabine in relapsed or refractory acute lymphoblastic leukemia. LEUKEMIA RESEARCH, 38(12), 1441鈥45. -
Chronic Myelogenous Leukemia, Version 1.2015 Clinical Practice Guidelines in Oncology
O'Brien, S., Radich, J. P., Abboud, C. N., Akhtari, M., Altman, J. K., Berman, E., 鈥 Sundar, H. (2014). Chronic Myelogenous Leukemia, Version 1.2015 Clinical Practice Guidelines in Oncology. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 12(11), 1590鈥1609. -
Mast Cells in Systemic Mastocytosis Have Distinctly Brighter CD45 Expression by Flow Cytometry
Chisholm, K. M., Merker, J. D., Gotlib, J. R., Gitana, G., Lefterova, M., Zehnder, J. L., 鈥 Ohgami, R. S. (2015). Mast Cells in Systemic Mastocytosis Have Distinctly Brighter CD45 Expression by Flow Cytometry. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 143(4), 527鈥34. -
Historical Views, Conventional Approaches, and Evolving Management Strategies for Myeloproliferative Neoplasms
Stein, B. L., Gotlib, J., Arcasoy, M., Nguyen, M. H., Shah, N., Moliterno, A., 鈥 Mesa, R. A. (2015). Historical Views, Conventional Approaches, and Evolving Management Strategies for Myeloproliferative Neoplasms. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 13(4), 424鈥34. -
Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I.
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. (2015). Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I. Haematologica, 100(4), 479鈥88. -
Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes
Verstovsek, S., Gotlib, J., Gupta, V., Atallah, E., Mascarenhas, J., Quintas-Cardama, A., 鈥 Mesa, R. A. (2014). Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes. ONCOTARGETS AND THERAPY, 7, 13鈥21. -
CME Information: World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management
Gotlib, J. (2014). CME Information: World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY, 89(3), 325鈥37. -
A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. M. (2012). A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis. NEW ENGLAND JOURNAL OF MEDICINE, 366(9), 799鈥807. -
Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening
Tyner, J. W., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., 鈥 Loriaux, M. M. (2013). Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening. CANCER RESEARCH, 73(1), 285鈥96. -
Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies
Mesa, R. A., Kiladjian, J.-J., Verstovsek, S., Al-Ali, H. K., Gotlib, J., Gisslinger, H., 鈥 Harrison, C. (2014). Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies. HAEMATOLOGICA, 99(2), 292鈥298. -
Soluble TNF receptor fusion protein (etanercept) for the treatment of myelodysplastic syndrome: A pilot study
Deeg, H. J., Gotlib, J., Beckham, C., Dugan, K., Holmberg, L., Schubert, M., 鈥 Greenberg, P. (2002). Soluble TNF receptor fusion protein (etanercept) for the treatment of myelodysplastic syndrome: A pilot study. LEUKEMIA, 16(2), 162鈥64. -
KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib
Gleixner, K. V., Mayerhofer, M., Cerny-Reiterer, S., Hoermann, G., Rix, U., Bennett, K. L., 鈥 Valent, P. (2011). KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. BLOOD, 118(7), 1885鈥1898. -
JAK inhibition in the myeloproliferative neoplasms: lessons learned from the bench and bedside
Gotlib, J. (2013). JAK inhibition in the myeloproliferative neoplasms: lessons learned from the bench and bedside. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 529鈥537. -
Hereditary erythrocytosis, thrombocytosis and neutrophilia
Hong, W.-J., & Gotlib, J. (2014). Hereditary erythrocytosis, thrombocytosis and neutrophilia. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 27(2), 95鈥106. -
Practical management of patients with myelofibrosis receiving ruxolitinib
Harrison, C., Mesa, R., Ross, D., Mead, A., Keohane, C., Gotlib, J., & Verstovsek, S. (2013). Practical management of patients with myelofibrosis receiving ruxolitinib. EXPERT REVIEW OF HEMATOLOGY, 6(5), 511鈥523. -
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
Pardanani, A., Lasho, T., Finke, C., Oh, S. T., Gotlib, J., & Tefferi, A. (2010). LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. LEUKEMIA, 24(10), 1713鈥1718. -
Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance
Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., 鈥 Lane, A. A. (2015). Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance. NATURE MEDICINE, 21(1), 71鈥75. -
Myeloid and lymphoid Neoplasms with FGFR1 abnormalities: diagnostic and therapeutic challenges
Savage, N. M., Johnson, R. C., Gotlib, J., & George, T. I. (2013). Myeloid and lymphoid Neoplasms with FGFR1 abnormalities: diagnostic and therapeutic challenges. AMERICAN JOURNAL OF HEMATOLOGY, 88(5), 427鈥430. -
Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, and FGFR1: a review
Savage, N., George, T. I., & Gotlib, J. (2013). Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, and FGFR1: a review. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 35(5), 491鈥500. -
The clinical benefit of ruxolitinib across patient subgroups: analysis of a placebo-controlled, Phase III study in patients with myelofibrosis
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. M. (2013). The clinical benefit of ruxolitinib across patient subgroups: analysis of a placebo-controlled, Phase III study in patients with myelofibrosis. BRITISH JOURNAL OF HAEMATOLOGY, 161(4), 508鈥516. -
Revised response criteria for myelofibrosis: International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) and European LeukemiaNet (ELN) consensus report
Tefferi, A., Cervantes, F., Mesa, R., Passamonti, F., Verstovsek, S., Vannucchi, A. M., 鈥 Barosi, G. (2013). Revised response criteria for myelofibrosis: International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) and European LeukemiaNet (ELN) consensus report. BLOOD, 122(8), 1395鈥1398. -
Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: A case review
Ustun, C., Savage, N. M., Gotlib, J., Bhalla, K., Manaloor, E., & George, T. I. (2012). Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: A case review. AMERICAN JOURNAL OF HEMATOLOGY, 87(2), 191鈥193. -
Altered translation of GATA1 in Diamond-Blackfan anemia
Ludwig, L. S., Gazda, H. T., Eng, J. C., Eichhorn, S. W., Thiru, P., Ghazvinian, R., 鈥 Sankaran, V. G. (2014). Altered translation of GATA1 in Diamond-Blackfan anemia. NATURE MEDICINE, 20(7), 748鈥53. -
Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: Proceedings from the 6th international post-ASH symposium
Abdel-Wahab, O., Pardanani, A., Bernard, O. A., Finazzi, G., Crispino, J. D., Gisslinger, H., 鈥 Tefferi, A. (2012). Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: Proceedings from the 6th international post-ASH symposium. AMERICAN JOURNAL OF HEMATOLOGY, 87(5), 562鈥568. -
Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. M. (2013). Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. HAEMATOLOGICA, 98(12), 1865鈥1871. -
Janus Kinase Inhibitors and Allogeneic Stem Cell Transplantation for Myelofibrosis
Gupta, V., Gotlib, J., Radich, J. P., Kroeger, N. M., Rondelli, D., Verstovsek, S., & Deeg, H. J. (2014). Janus Kinase Inhibitors and Allogeneic Stem Cell Transplantation for Myelofibrosis. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 20(9), 1274鈥81. -
Salvage therapy with mitoxantrone, etoposide and cytarabine in relapsed or refractory acute lymphoblastic leukemia.
Liedtke, M., Dunn, T., Dinner, S., Coutr茅, S. E., Berube, C., Gotlib, J., 鈥 Medeiros, B. (2014). Salvage therapy with mitoxantrone, etoposide and cytarabine in relapsed or refractory acute lymphoblastic leukemia. Leukemia Research, 38(12), 1441鈥45. -
Clinical activity of ponatinib in a patient with FGFR1-rearranged mixed-phenotype acute leukemia.
Khodadoust, M. S., Luo, B., Medeiros, B. C., Johnson, R. C., Ewalt, M. D., Schalkwyk, A. S., 鈥 Gotlib, J. (2016). Clinical activity of ponatinib in a patient with FGFR1-rearranged mixed-phenotype acute leukemia. Leukemia, 30(4), 947鈥50. -
KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis
Arock, M., Sotlar, K., Akin, C., Broesby-Olsen, S., Hoermann, G., Escribano, L., 鈥 Valent, P. (2015). KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis. LEUKEMIA, 29(6), 1223鈥1232. -
Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. (2015). Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I. HAEMATOLOGICA, 100(4), 482鈥91. -
Effects of Ruxolitinib Treatment on Metabolic and Nutritional Parameters in Patients With Myelofibrosis From COMFORT-I
Mesa, R. A., Verstoysek, S., Gupta, V., Mascarenhas, J. O., Atallah, E., Burn, T., 鈥 Gotlib, J. (2015). Effects of Ruxolitinib Treatment on Metabolic and Nutritional Parameters in Patients With Myelofibrosis From COMFORT-I. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 15(4), 214鈥221. -
Sequential azacitidine plus lenalidomide in previously treated elderly patients with acute myeloid leukemia and higher risk myelodysplastic syndrome.
Narayan, R., Garcia, J. S., Percival, M.-E. M., Berube, C., Coutre, S., Gotlib, J., 鈥 Medeiros, B. C. (2016). Sequential azacitidine plus lenalidomide in previously treated elderly patients with acute myeloid leukemia and higher risk myelodysplastic syndrome. Leukemia & Lymphoma, 57(3), 609鈥15. -
Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis
Sasaki, K., Gotlib, J. R., Mesa, R. A., Newberry, K. J., Ravandi, F., Cortes, J. E., 鈥 Verstovsek, S. (2015). Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis. LEUKEMIA & LYMPHOMA, 56(7), 2092鈥2097. -
The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.
Maxson, J. E., Luty, S. B., Macmaniman, J. D., Paik, J. C., Gotlib, J., Greenberg, P., 鈥 Tyner, J. W. (2016). The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I. Clinical Cancer Research , 22(3), 757鈥64. -
Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis
Gotlib, J. (2015). Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 10(4), 351鈥61. -
A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis
Vannucchi, A. M., Kantarjian, H. M., Kiladjian, J.-J., Gotlib, J., Cervantes, F., Mesa, R. A., 鈥 Verstovsek, S. (2015). A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis. HAEMATOLOGICA, 100(9), 1139鈥45. -
Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis
Jamieson, C., Hasserjian, R., Gotlib, J., Cortes, J., Stone, R., Talpaz, M., 鈥 Pozdnyakova, O. (2015). Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis. JOURNAL OF TRANSLATIONAL MEDICINE, 13. -
Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology
Hartmann, K., Escribano, L., Grattan, C., Brockow, K., Carter, M. C., Alvarez-Twose, I., 鈥 Valent, P. (2016). Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(1), 35鈥45. -
A phase 1, open-label, dose-escalation study of pralatrexate in听combination with bortezomib in patients with relapsed/refractory multiple myeloma.
Dunn, T. J., Dinner, S., Price, E., Coutr茅, S. E., Gotlib, J., Hao, Y., 鈥 Liedtke, M. (2016). A phase 1, open-label, dose-escalation study of pralatrexate in听combination with bortezomib in patients with relapsed/refractory multiple myeloma. British Journal of Haematology, 173(2), 253鈥59. -
Sequential azacitidine plus lenalidomide in previously treated elderly patients with acute myeloid leukemia and higher risk myelodysplastic syndrome
Narayan, R., Garcia, J. S., Percival, M.-E. M., Berube, C., Coutre, S., Gotlib, J., 鈥 Medeiros, B. C. (2016). Sequential azacitidine plus lenalidomide in previously treated elderly patients with acute myeloid leukemia and higher risk myelodysplastic syndrome. LEUKEMIA & LYMPHOMA, 57(3), 609鈥15. -
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
Loh, M. L., Vattikuti, S., Schubbert, S., Reynolds, M. G., Carlson, E., Lieuw, K. H., 鈥 Shannon, K. M. (2004). Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. BLOOD, 103(6), 2325鈥31. -
Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes.
Verstovsek, S., Gotlib, J., Gupta, V., Atallah, E., Mascarenhas, J., Quintas-Cardama, A., 鈥 Mesa, R. A. (2013). Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes. OncoTargets and Therapy, 7, 13鈥21. -
Insights into the molecular genetics of myeloproliferative neoplasms.
Nguyen, H. M., & Gotlib, J. (2012). Insights into the molecular genetics of myeloproliferative neoplasms. American Society of Clinical Oncology Educational Book / ASCO. American Society of Clinical Oncology. Meeting, 411鈥18. -
NCCN clinical practice guidelines in oncology: chronic myelogenous leukemia.
O'Brien, S., Berman, E., Borghaei, H., DeAngelo, D. J., Devetten, M. P., Devine, S., 鈥 Wetzler, M. (2009). NCCN clinical practice guidelines in oncology: chronic myelogenous leukemia. Journal of the National Comprehensive Cancer Network , 7(9), 984鈥1023. -
Age-related mutations and chronic myelomonocytic leukemia
Mason, C. C., Khorashad, J. S., Tantravahi, S. K., Kelley, T. W., Zabriskie, M. S., Yan, D., 鈥 Deininger, M. W. (2016). Age-related mutations and chronic myelomonocytic leukemia. LEUKEMIA, 30(4), 906鈥13. -
Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis
Gotlib, J., Kluin-Nelemans, H. C., George, T. I., Akin, C., Sotlar, K., Hermine, O., 鈥 Reiter, A. (2016). Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis. NEW ENGLAND JOURNAL OF MEDICINE, 374(26), 2530鈥41. -
Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms.
Hinds, D. A., Barnholt, K. E., Mesa, R. A., Kiefer, A. K., Do, C. B., Eriksson, N., 鈥 Gotlib, J. (2016). Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms. Blood, 128(8), 1121鈥28. -
Complete response to gemtuzumab ozogamicin in a patient with refractory mast cell leukemia.
Alvarez-Twose, I., Mart铆nez-Barranco, P., Gotlib, J., Garc铆a-Montero, A., Morgado, J. M., Jara-Acevedo, M., 鈥 Orfao, A. (2016). Complete response to gemtuzumab ozogamicin in a patient with refractory mast cell leukemia. Leukemia, 30(8), 1753鈥1756. -
Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.
Ustun, C., Arock, M., Kluin-Nelemans, H. C., Reiter, A., Sperr, W. R., George, T., 鈥 Valent, P. (2016). Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice. Haematologica, 101(10), 1133鈥43. -
The clinicopathologic significance of lymphocyte subsets in acute myeloid leukemia.
Alcasid, M., Ma, L., Gotlib, J. R., Arber, D. A., & Ohgami, R. S. (2017). The clinicopathologic significance of lymphocyte subsets in acute myeloid leukemia. International Journal of Laboratory Hematology. -
NCCN Guidelines (R) Insights Chronic Myeloid Leukemia, Version 1.2017 Featured Updates to the NCCN Guidelines
Pallera, A., Altman, J. K., Berman, E., Abboud, C. N., Bhatnagar, B., Curtin, P., 鈥 Radich, J. P. (2016). NCCN Guidelines (R) Insights Chronic Myeloid Leukemia, Version 1.2017 Featured Updates to the NCCN Guidelines. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 14(12), 1505鈥12. -
Myeloproliferative Neoplasms, Version 2.2017
Mesa, R., Jamieson, C., Bhatia, R., Deininger, M. W., Gerds, A. T., Gojo, I., 鈥 Sundar, H. (2016). Myeloproliferative Neoplasms, Version 2.2017. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 14(12), 1572鈥1611. -
Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial.
Verstovsek, S., Mesa, R. A., Gotlib, J., Gupta, V., DiPersio, J. F., Catalano, J. V., 鈥 Kantarjian, H. (2017). Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial. Journal of Hematology & Oncology, 10(1), 55-? -
Chronic Myelogenous Leukemia, Version 1.2014.
O'Brien, S., Radich, J. P., Abboud, C. N., Akhtari, M., Altman, J. K., Berman, E., 鈥 Sundar, H. (2013). Chronic Myelogenous Leukemia, Version 1.2014. Journal of the National Comprehensive Cancer Network , 11(11), 1327鈥40. -
Chronic myelogenous leukemia, version 1.2015.
O'Brien, S., Radich, J. P., Abboud, C. N., Akhtari, M., Altman, J. K., Berman, E., 鈥 Sundar, H. (2014). Chronic myelogenous leukemia, version 1.2015. Journal of the National Comprehensive Cancer Network , 12(11), 1590鈥1610. -
Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.
Mesa, R., Jamieson, C., Bhatia, R., Deininger, M. W., Gerds, A. T., Gojo, I., 鈥 Sundar, H. (2016). Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network , 14(12), 1572鈥1611. -
Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.
Valent, P., Sotlar, K., Blatt, K., Hartmann, K., Reiter, A., Sadovnik, I., 鈥 Arock, M. (2017). Proposed diagnostic criteria and classification of basophilic leukemias and related disorders. Leukemia. -
Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.
Valent, P., Akin, C., Hartmann, K., Nilsson, G., Reiter, A., Hermine, O., 鈥 Metcalfe, D. D. (2017). Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future. Cancer Research. -
A phase 2 study of simtuzumab in patients with primary, post-polycythaemia vera or post-essential thrombocythaemia myelofibrosis.
Verstovsek, S., Savona, M. R., Mesa, R. A., Dong, H., Maltzman, J. D., Sharma, S., 鈥 Gotlib, J. (2017). A phase 2 study of simtuzumab in patients with primary, post-polycythaemia vera or post-essential thrombocythaemia myelofibrosis. British Journal of Haematology. -
How I treat atypical chronic myeloid leukemia
Gotlib, J. (2017). How I treat atypical chronic myeloid leukemia. BLOOD, 129(7), 838鈥45. -
Myeloid neoplasms with eosinophilia
Reiter, A., & Gotlib, J. (2017). Myeloid neoplasms with eosinophilia. BLOOD, 129(6), 704鈥14. -
Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens
Shoura, M., Gabdank, I., Merker, J., Gotlib, J., Levene, S., & Fire, A. (2017). Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens. G3: GENES, GENOMES, GENETICS , 7, 3295鈥3303. -
The Significance of CD56 Expression and the RAM Immunophenotype, a Recurrent Immunophenotype Seen in Children, in Adult Acute Myeloid Leukemia
Lazzareschi, D., Cherry, A., Zehnder, J., Gotlib, J., Arber, D. A., Lacayo, N., & Ohgami, R. (2017). The Significance of CD56 Expression and the RAM Immunophenotype, a Recurrent Immunophenotype Seen in Children, in Adult Acute Myeloid Leukemia. LABORATORY INVESTIGATION, 97, 358A鈥359A. -
A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia
Chung, A., Hou, Y., Ohgami, R. S., Von Gehr, A., Fisk, D. G., Roskin, K. M., 鈥 Merker, J. D. (2017). A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia. CANCER GENETICS, 216, 10鈥15. -
The Significance of CD56 Expression and the RAM Immunophenotype, a Recurrent Immunophenotype Seen in Children, in Adult Acute Myeloid Leukemia
Lazzareschi, D., Cherry, A., Zehnder, J., Gotlib, J., Arber, D. A., Lacayo, N., & Ohgami, R. (2017). The Significance of CD56 Expression and the RAM Immunophenotype, a Recurrent Immunophenotype Seen in Children, in Adult Acute Myeloid Leukemia. MODERN PATHOLOGY, 30, 358A鈥359A. -
Variability of PD-L1 expression in mastocytosis
Hatch, E. W., Geeze, M. B., Martin, C., Salama, M. E., Hartmann, K., Eisenwort, G., 鈥 George, T. I. (2018). Variability of PD-L1 expression in mastocytosis. BLOOD ADVANCES, 2(3), 189鈥99. -
Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal
Valent, P., Akin, C., Arock, M., Bock, C., George, T. I., Galli, S. J., 鈥 Horny, H.-P. (2017). Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal. EBIOMEDICINE, 26, 17鈥24. -
Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist
Shih, A. Y., Schairer, A., Barrett, C. L., Geron, I., Recart, A. C. C., Goff, D., 鈥 Jamieson, C. (2011). Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist. BLOOD, 118(21), 1613. -
The Significance of Morphologic Dysplasia in 432 Cases of Acute Lymphoblastic Leukemia and Acute Leukemia of Ambiguous Lineage: Correlation with Cytogenetic, Immunophenotypic, and Molecular Findings
Segal, J., Dahl, G., Lacayo, N., Gotlib, J., & Ohgami, R. (2017). The Significance of Morphologic Dysplasia in 432 Cases of Acute Lymphoblastic Leukemia and Acute Leukemia of Ambiguous Lineage: Correlation with Cytogenetic, Immunophenotypic, and Molecular Findings. MODERN PATHOLOGY, 30, 376A. -
Detailed Multiparameter Flow Cytometry Study of 365 Cases of B-Lymphoblastic Leukemia with Subtyping According to the 2016 WHO: A Single Institutional Study
Segal, J., Lacayo, N., Gotlib, J., & Ohgamt, R. (2017). Detailed Multiparameter Flow Cytometry Study of 365 Cases of B-Lymphoblastic Leukemia with Subtyping According to the 2016 WHO: A Single Institutional Study. MODERN PATHOLOGY, 30, 376A. -
A Detailed Multi parameter Flow Cytometry Study of 365 Cases of B-Lymphoblastic Leukemia with Subtyping According to the 2016 WHO: A Single Institutional Study
Segal, J., Lacayo, N., Gotlib, J., & Ohgami, R. (2017). A Detailed Multi parameter Flow Cytometry Study of 365 Cases of B-Lymphoblastic Leukemia with Subtyping According to the 2016 WHO: A Single Institutional Study. LABORATORY INVESTIGATION, 97, 376A. -
The Significance of Morphologic Dysplasia in 432 Cases of Acute Lymphoblastic Leukemia and Acute Leukemia of Ambiguous Lineage: Correlation with Cytogenetic, Immunophenotypic, and Molecular Findings
Segal, J., Dahl, G., Lacayo, N., Gotlib, J., & Ohgami, R. (2017). The Significance of Morphologic Dysplasia in 432 Cases of Acute Lymphoblastic Leukemia and Acute Leukemia of Ambiguous Lineage: Correlation with Cytogenetic, Immunophenotypic, and Molecular Findings. LABORATORY INVESTIGATION, 97, 376A. -
Allogeneic NK cells eradicate myeloblasts but not neoplastic mast cells in systemic mastocytosis associated with acute myeloid leukemia
Ustun, C., Williams, S., Skendzel, S., Kodal, B., Arock, M., Gotlib, J., 鈥 Miller, J. (2017). Allogeneic NK cells eradicate myeloblasts but not neoplastic mast cells in systemic mastocytosis associated with acute myeloid leukemia. AMERICAN JOURNAL OF HEMATOLOGY, 92(5), E66鈥揈68. -
The Significance of Dim Cytoplasmic CD3 Expression in Acute Myeloid Leukemia: A Long-Term Retrospective Study Identifies an Association with Acute Promyelocytic Leukemia with FLT3-ITD Mutations
Kumar, J., Nagy, A., Lacayo, N., Gotlib, J., Zehnder, J. L., & Ohgami, R. (2018). The Significance of Dim Cytoplasmic CD3 Expression in Acute Myeloid Leukemia: A Long-Term Retrospective Study Identifies an Association with Acute Promyelocytic Leukemia with FLT3-ITD Mutations. MODERN PATHOLOGY, 31, 529. -
Amrubicin, a Novel Investigational Anthracycline, in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Results of a Phase 1 Dose-Escalation Study
Dinner, S. N., Dunn, T. J., Medeiros, B. C., Coutre, S. E., Berube, C., Gotlib, J., & Liedtke, M. (2012). Amrubicin, a Novel Investigational Anthracycline, in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Results of a Phase 1 Dose-Escalation Study. BLOOD. AMER SOC HEMATOLOGY. -
Azacitidine Plus Lenalidomide for Untreated AML Patients Ineligible for Conventional Chemotherapy
Pollyea, D. A., Zehnder, J. L., Coutre, S., Gotlib, J., Gallegos, L., Greenberg, P., 鈥 Medeiros, B. C. (2012). Azacitidine Plus Lenalidomide for Untreated AML Patients Ineligible for Conventional Chemotherapy. BLOOD. AMER SOC HEMATOLOGY. -
GNB1 Activating Mutations Promote Myeloid and Lymphoid Neoplasms Targetable By Combined PI3K/mTOR Inhibition
Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., 鈥 Lane, A. A. (2014). GNB1 Activating Mutations Promote Myeloid and Lymphoid Neoplasms Targetable By Combined PI3K/mTOR Inhibition. BLOOD, 124(21). -
A phase I, open-label, dose-escalation study of amrubicin in combination with lenalidomide and weekly dexamethasone in previously treated adults with relapsed or refractory multiple myeloma.
Dinner, S., Dunn, T. J., Price, E., Coutr茅, S. E., Gotlib, J., Berube, C., 鈥 Liedtke, M. (2018). A phase I, open-label, dose-escalation study of amrubicin in combination with lenalidomide and weekly dexamethasone in previously treated adults with relapsed or refractory multiple myeloma. International Journal of Hematology. -
Phase 2 trial of PRM-151, an antifibrotic agent, in patients with myelofibrosis: Stage 1 results.
Verstovsek, S., Mesa, R. A., Foltz, L. M., Gupta, V., Mascarenhas, J., Ritchie, E. K., 鈥 Gotlib, J. R. (2014). Phase 2 trial of PRM-151, an antifibrotic agent, in patients with myelofibrosis: Stage 1 results. JOURNAL OF CLINICAL ONCOLOGY, 32(15). -
SIMPLIFY-1: A Phase III Randomized Trial of Momelotinib Versus Ruxolitinib in Janus Kinase Inhibitor-Naive Patients With Myelofibrosis.
Mesa, R. A., Kiladjian, J.-J., Catalano, J. V., Devos, T., Egyed, M., Hellmann, A., 鈥 Gotlib, J. (2017). SIMPLIFY-1: A Phase III Randomized Trial of Momelotinib Versus Ruxolitinib in Janus Kinase Inhibitor-Naive Patients With Myelofibrosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, JCO2017734418. -
Trispecific Killer Engager CD16xIL15xCD33 Enhances Alloreactivity of NK Cells Against Aberrant Mast Cells of Patients with Systemic Mastocytosis
Yun, H. D., Felices, M., Vallera, D. A., Cooley, S., Gotlib, J. R., Ustun, C., & Miller, J. S. (2018). Trispecific Killer Engager CD16xIL15xCD33 Enhances Alloreactivity of NK Cells Against Aberrant Mast Cells of Patients with Systemic Mastocytosis. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 24(3), S148鈥揝149. -
Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms
Mughal, T. I., Gotlib, J., Mesa, R., Koschmieder, S., Khoury, H. J., Cortes, J. E., 鈥 Abdel-Wahab, O. (2018). Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms. LEUKEMIA RESEARCH, 67, 67鈥74. -
Treatment With JAK Inhibitors in Myelofibrosis Patients Nullifies the Prognostic Impact of Unfavorable Cytogenetics
Ma, V. T., Boonstra, P. S., Menghrajani, K., Perkins, C., Gowin, K. L., Mesa, R. A., 鈥 Talpaz, M. (2018). Treatment With JAK Inhibitors in Myelofibrosis Patients Nullifies the Prognostic Impact of Unfavorable Cytogenetics. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 18(5), E201鈥揈210. -
Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis A Randomized Clinical Trial
Mascarenhas, J., Hoffman, R., Talpaz, M., Gerds, A. T., Stein, B., Gupta, V., 鈥 Verstovsek, S. (2018). Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis A Randomized Clinical Trial. JAMA ONCOLOGY, 4(5), 652鈥59. -
Myelophthisic marrow involved by breast cancer and acute myeloid leukemia
Shomali, W., & Gotlib, J. (2018). Myelophthisic marrow involved by breast cancer and acute myeloid leukemia. BLOOD, 131(9), 1036. -
SOHO State-of-the-Art Update and Next Questions: MPN
Bose, P., Gotlib, J., Harrison, C. N., & Verstovsek, S. (2018). SOHO State-of-the-Art Update and Next Questions: MPN. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 18(1), 1鈥12. -
Phenotype variability of patients with post polycythemia vera and post essential thrombocythemia myelofibrosis is associated with the time to progression from polycythemia vera and essential thrombocythemia
Mora, B., Giorgino, T., Guglielmelli, P., Rumi, E., Maffioli, M., Rambaldi, A., 鈥 Passamonti, F. (2018). Phenotype variability of patients with post polycythemia vera and post essential thrombocythemia myelofibrosis is associated with the time to progression from polycythemia vera and essential thrombocythemia. LEUKEMIA RESEARCH, 69, 100鈥102. -
Trispecific killer engager CD16xIL15xCD33 potently induces NK cell activation and cytotoxicity against neoplastic mast cells
Yun, H. D., Felices, M., Vallera, D. A., Hinderlie, P., Cooley, S., Arock, M., 鈥 Miller, J. S. (2018). Trispecific killer engager CD16xIL15xCD33 potently induces NK cell activation and cytotoxicity against neoplastic mast cells. BLOOD ADVANCES, 2(13), 1580鈥84. -
Clinical Validation of KIT Inhibition in Advanced Systemic Mastocytosis.
Baird, J. H., & Gotlib, J. (2018). Clinical Validation of KIT Inhibition in Advanced Systemic Mastocytosis. Current Hematologic Malignancy Reports. -
Tailored Temozolomide Therapy for Elderly Patients with Acute Myeloid Leukemia.
Medeiros, B. C., Gotlib, J. R., Coutre, S. E., Mignea, A., & Zehnder, J. (2008). Tailored Temozolomide Therapy for Elderly Patients with Acute Myeloid Leukemia. BLOOD, 112(11), 351. -
Value of cytogenetic abnormalities in post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a study of the MYSEC project
Mora, B., Giorgino, T., Guglielmelli, P., Rumi, E., Maffioli, M., Rambaldi, A., 鈥 Passamonti, F. (2018). Value of cytogenetic abnormalities in post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a study of the MYSEC project. HAEMATOLOGICA, 103(9), E392鈥揈394. -
Chronic Myeloid Leukemia, Version 1.2019 Clinical Practice Guidelines in Oncology
Radich, J. P., Deininger, M., Abboud, C. N., Altman, J. K., Berman, E., Bhatia, R., 鈥 Sundar, H. (2018). Chronic Myeloid Leukemia, Version 1.2019 Clinical Practice Guidelines in Oncology. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 16(9), 1108鈥35. -
Mast cell activation syndrome: Importance of consensus criteria and call for 糖心传媒
Valent, P., Akin, C., Bonadonna, P., Hartmann, K., Broesby-Olsen, S., Brockow, K., 鈥 Metcalfe, D. D. (2018). Mast cell activation syndrome: Importance of consensus criteria and call for 糖心传媒. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(3), 1008-+. -
Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia
Dao, K.-H. T., Tyner, J. W., & Gotlib, J. (2017). Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 12(5), 432鈥41. -
World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management
Gotlib, J. (2017). World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY, 92(11), 1243鈥59. -
NCCN Guidelines (R) Insights Myeloproliferative Neoplasms, Version 2.2018 Featured Updates to the NCCN Guidelines
Mesa, R. A., Jamieson, C., Bhatia, R., Deininger, M. W., Fletcher, C. D., Gerds, A. T., 鈥 Sundar, H. (2017). NCCN Guidelines (R) Insights Myeloproliferative Neoplasms, Version 2.2018 Featured Updates to the NCCN Guidelines. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 15(10), 1193鈥1207. -
Long-term survival in patients treated with ruxolitinib for myelofibrosis: COMFORT-I and -II pooled analyses
Verstovsek, S., Gotlib, J., Mesa, R. A., Vannucchi, A. M., Kiladjian, J.-J., Cervantes, F., 鈥 Gupta, V. (2017). Long-term survival in patients treated with ruxolitinib for myelofibrosis: COMFORT-I and -II pooled analyses. JOURNAL OF HEMATOLOGY & ONCOLOGY, 10, 156. -
Tyrosine Kinase Inhibitors in the Treatment of Eosinophilic Neoplasms and Systemic Mastocytosis
Gotlib, J. (2017). Tyrosine Kinase Inhibitors in the Treatment of Eosinophilic Neoplasms and Systemic Mastocytosis. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 31(4), 643-+. -
A molecular roadmap for midostaurin in mastocytosis
Gotlib, J. (2017). A molecular roadmap for midostaurin in mastocytosis. BLOOD, 130(2), 98鈥100. -
Quantitative Analysis of Ki67 in Mastocytosis Distinguishes Mast Cell Leukemia from Other Subtypes
Sojitra, P., Hatch, E. W., Martin, C., Gotlib, J. R., Ward, H., Lidke, D. S., & Geoige, T. (2017). Quantitative Analysis of Ki67 in Mastocytosis Distinguishes Mast Cell Leukemia from Other Subtypes. MODERN PATHOLOGY, 30, 378A. -
Mast Cell Leukemia (MCL); Clinicopathologic Features of a Rare Disease
Davion, S., Wang, S., Silva, O., Sadigh, S., Arber, D. A., Bagg, A., 鈥 George, T. (2017). Mast Cell Leukemia (MCL); Clinicopathologic Features of a Rare Disease. MODERN PATHOLOGY, 30, 345A. -
Quantitative Analysis of Ki67 in Mastocytosis Distinguishes Mast Cell Leukemia from Other Subtypes
Sojitra, P., Hatch, E. W., Martin, C., Gotlib, J. R., Ward, H., Lidke, D. S., & George, T. (2017). Quantitative Analysis of Ki67 in Mastocytosis Distinguishes Mast Cell Leukemia from Other Subtypes. LABORATORY INVESTIGATION, 97, 378A. -
Mast Cell Leukemia (MCL); Clinicopathologic Features of a Rare Disease
Davion, S., Wang, S., Silva, O., Sadigh, S., Arber, D. A., Bagg, A., 鈥 George, T. (2017). Mast Cell Leukemia (MCL); Clinicopathologic Features of a Rare Disease. LABORATORY INVESTIGATION, 97, 345A. -
Prognostic Factors and Survival Prediction in 1,088 Patients with Mastocytosis Collected in the Registry of the European Competence Network on Mastocytosis (ECNM Registry)
Sperr, W. R., Kundi, M., Elberink, H. O., van Anrooij, B., Gleixner, K. V., Hadzijusufovic, E., 鈥 Valent, P. (2016). Prognostic Factors and Survival Prediction in 1,088 Patients with Mastocytosis Collected in the Registry of the European Competence Network on Mastocytosis (ECNM Registry). BLOOD, 128(22). -
Consensus Opinion on Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis
Ustun, C., Gotlib, J., Popat, U., Artz, A., Litzow, M., Reiter, A., 鈥 Valent, P. (2016). Consensus Opinion on Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 22(8), 1348鈥56. -
To Treat or Not to Treat: A Novel Stratification of Myelofibrosis Patients by Likelihood of Response to JAK2 Inhibitors
Menghrajani, K., Boonstra, P. S., Weber, A., Perkins, C., Gowin, K., Huong Nguyen, 鈥 Talpaz, M. (2015). To Treat or Not to Treat: A Novel Stratification of Myelofibrosis Patients by Likelihood of Response to JAK2 Inhibitors. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 15, S236. -
PD-1/PD-L1 Are Novel Therapeutic Targets for Mastocytosis
Geeze, M., Hatch, E., Martin, C., Perkins, S. L., Hartmann, K., Valent, P., 鈥 George, T. I. (2016). PD-1/PD-L1 Are Novel Therapeutic Targets for Mastocytosis. MODERN PATHOLOGY, 29, 346A. -
PRM-151 in Myelofibrosis: Durable Efficacy and Safety at 72 Weeks
Verstovsek, S., Mesa, R. A., Foltz, L. M., Gupta, V., Mascarenhas, J. O., Ritchie, E. K., 鈥 Gotlib, J. (2015). PRM-151 in Myelofibrosis: Durable Efficacy and Safety at 72 Weeks. BLOOD, 126(23). -
A Phase 2 Study to Evaluate the Efficacy and Safety of Simtuzumab in Adult Subjects with Primary, Post Polycythemia Vera (PV) or Post Essential Thrombocythemia (ET) Myelofibrosis
Verstovsek, S., Savona, M. R., Mesa, R. A., Oh, S., Dong, H., Thai, D., & Gotlib, J. (2015). A Phase 2 Study to Evaluate the Efficacy and Safety of Simtuzumab in Adult Subjects with Primary, Post Polycythemia Vera (PV) or Post Essential Thrombocythemia (ET) Myelofibrosis. BLOOD. AMER SOC HEMATOLOGY. -
PD-1/PD-L1 Are Novel Therapeutic Targets for Mastocytosis
Geeze, M., Hatch, E., Martin, C., Perkins, S. L., Hartmann, K., Valent, P., 鈥 George, T. I. (2016). PD-1/PD-L1 Are Novel Therapeutic Targets for Mastocytosis. LABORATORY INVESTIGATION, 96, 346A. -
World Health Organization-defined eosinophilic disorders: 2015 update on diagnosis, risk stratification, and management
Gotlib, J. (2015). World Health Organization-defined eosinophilic disorders: 2015 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY, 90(11), 1078鈥89. -
A phase 2 study of IPI-926, an oral hedgehog inhibitor, in patients with myelofibrosis.
Sasaki, K., Gotlib, J. R., Mesa, R. A., Ravandi, F., Cortes, J. E., Kelly, P. F., 鈥 Verstovsek, S. (2014). A phase 2 study of IPI-926, an oral hedgehog inhibitor, in patients with myelofibrosis. JOURNAL OF CLINICAL ONCOLOGY, 32(15). -
Eosinophilic myeloproliferative disorders
Gotlib, J. (2014). Eosinophilic myeloproliferative disorders. CANCER CONSULT: EXPERTISE FOR CLINICAL PRACTICE, 167鈥75. -
A New Prognostic Model for Response in Myelofibrosis Patients Treated with JAK2 Inhibitors: A Study from Three US Academic Centers
Kamal, M., Boonstra, P. S., Weber, A. A., Perkins, C., Gowin, K. L., Huong (Marie) Nguyen, 鈥 Talpaz, M. (2014). A New Prognostic Model for Response in Myelofibrosis Patients Treated with JAK2 Inhibitors: A Study from Three US Academic Centers. BLOOD, 124(21). -
A New International Multicenter-Based Model to Predict Survival in Myelofibrosis Secondary to Polycythemia and Thrombocythemia: The Mysec Prognostic Model (MYSEC-PM)
Passamonti, F., Alessandro, V., Domenica, C., Alessandro, R., Enrica, M., Jacques, K. J., 鈥 Cazzola, M. (2014). A New International Multicenter-Based Model to Predict Survival in Myelofibrosis Secondary to Polycythemia and Thrombocythemia: The Mysec Prognostic Model (MYSEC-PM). BLOOD, 124(21). -
Midostaurin (PKC412) Demonstrates a High Rate of Durable Responses in Patients with Advanced Systemic Mastocytosis: Results from the Fully Accrued Global Phase 2 CPKC412D2201 Trial
Gotlib, J., Kluin-Nelemans, H. C., George, T. I., Akin, C., Sotlar, K., Hermine, O., 鈥 Reiter, A. (2014). Midostaurin (PKC412) Demonstrates a High Rate of Durable Responses in Patients with Advanced Systemic Mastocytosis: Results from the Fully Accrued Global Phase 2 CPKC412D2201 Trial. BLOOD, 124(21). -
Next Generation Sequencing to Delineate the Mutational Landscape of Chronic Myelomonocytic Leukemia (CMML): Novel Disease Genes and Correlations with Survival
Mason, C. C., Khorashad, J. S., Tantravahi, S. K., Kelley, T. W., Pomicter, A. D., Iovino, A. J., 鈥 Deininger, M. W. (2014). Next Generation Sequencing to Delineate the Mutational Landscape of Chronic Myelomonocytic Leukemia (CMML): Novel Disease Genes and Correlations with Survival. BLOOD, 124(21). -
Phase 2 Trial of PRM-151, an Anti-Fibrotic Agent, in Patients with Myelofibrosis: Stage 1 Results
Verstovsek, S., Mesa, R. A., Foltz, L. M., Gupta, V., Mascarenhas, J. O., Ritchie, E. K., 鈥 Gotlib, J. R. (2014). Phase 2 Trial of PRM-151, an Anti-Fibrotic Agent, in Patients with Myelofibrosis: Stage 1 Results. BLOOD, 124(21). -
Two faces of ET: CALR and JAK2
Chao, M. P., & Gotlib, J. (2014). Two faces of ET: CALR and JAK2. BLOOD, 123(10), 1438鈥40. -
Adverse events (AEs) and the return of myelofibrosis (MF)-related symptoms after interruption or discontinuation of ruxolitinib (RUX) therapy.
Verstovsek, S., Mesa, R. A., Gotlib, J. R., Gupta, V., DiPersio, J. F., Catalano, J. V., 鈥 Kantarjian, H. (2012). Adverse events (AEs) and the return of myelofibrosis (MF)-related symptoms after interruption or discontinuation of ruxolitinib (RUX) therapy. JOURNAL OF CLINICAL ONCOLOGY, 30(15). -
Improvement in Weight and Total Cholesterol and Their Association with Survival in Ruxolitinib-Treated Patients with Myelofibrosis From COMFORT-I
Mesa, R. A., Verstovsek, S., Gupta, V., Mascarenhas, J., Atallah, E., Sun, W., 鈥 Gotlib, J. (2012). Improvement in Weight and Total Cholesterol and Their Association with Survival in Ruxolitinib-Treated Patients with Myelofibrosis From COMFORT-I. BLOOD, 120(21). -
Clinical Benefits of Ruxolitinib Therapy in Myelofibrosis Patients with Varying Degrees of Splenomegaly and Symptoms
Mesa, R. A., Gotlib, J., Kantarjian, H. M., Sun, W., & Verstovsek, S. (2012). Clinical Benefits of Ruxolitinib Therapy in Myelofibrosis Patients with Varying Degrees of Splenomegaly and Symptoms. BLOOD, 120(21). -
Effect of Ruxolitinib On the Incidence of Splenectomy in Patients with Myelofibrosis: A Retrospective Analysis of Data From Ruxolitinib Clinical Trials
Verstovsek, S., Kiladjian, J.-J., Mesa, R. A., Vannucchi, A. M., Gotlib, J., Barosi, G., 鈥 Harrison, C. N. (2012). Effect of Ruxolitinib On the Incidence of Splenectomy in Patients with Myelofibrosis: A Retrospective Analysis of Data From Ruxolitinib Clinical Trials. BLOOD. AMER SOC HEMATOLOGY. -
Phase I/II Study of CYT387, a JAK1/JAK2 Inhibitor for the Treatment of Myelofibrosis
Pardanani, A., Gotlib, J., Gupta, V., Roberts, A. W., Wadleigh, M., Sirhan, S., 鈥 Tefferi, A. (2012). Phase I/II Study of CYT387, a JAK1/JAK2 Inhibitor for the Treatment of Myelofibrosis. BLOOD, 120(21). -
A Germline Variant in the TERT Gene Is a Novel Predisposition Allele Associated with Myeloproliferative Neoplasms
Hinds, D. A., Barnholt, K. E., Zehnder, J. L., Kiefer, A. K., Do, C. B., Eriksson, N., 鈥 Gotlib, J. (2012). A Germline Variant in the TERT Gene Is a Novel Predisposition Allele Associated with Myeloproliferative Neoplasms. BLOOD. AMER SOC HEMATOLOGY. -
Long-Term Outcome of Ruxolitinib Treatment in Patients with Myelofibrosis: Durable Reductions in Spleen Volume, Improvements in Quality of Life, and Overall Survival Advantage in COMFORT-I
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., 鈥 Kantarjian, H. M. (2012). Long-Term Outcome of Ruxolitinib Treatment in Patients with Myelofibrosis: Durable Reductions in Spleen Volume, Improvements in Quality of Life, and Overall Survival Advantage in COMFORT-I. BLOOD, 120(21). -
KIT Inhibitor Midostaurin in Patients with Advanced Systemic Mastocytosis: Results of a Planned Interim Analysis of the Global CPKC412D2201 Trial
Gotlib, J., Kluin-Nelemans, H. C., George, T. I., Akin, C., Sotlar, K., Hermine, O., 鈥 Reiter, A. (2012). KIT Inhibitor Midostaurin in Patients with Advanced Systemic Mastocytosis: Results of a Planned Interim Analysis of the Global CPKC412D2201 Trial. BLOOD, 120(21). -
An Expanded Multicenter Phase I/II Study of CYT387, a JAK-1/2 Inhibitor for the Treatment of Myelofibrosis
Pardanani, A., Gotlib, J., Gupta, V., Roberts, A. W., Wadleigh, M., Sirhan, S., 鈥 Tefferi, A. (2011). An Expanded Multicenter Phase I/II Study of CYT387, a JAK-1/2 Inhibitor for the Treatment of Myelofibrosis. BLOOD, 118(21), 1645. -
Associations Between Improvements in Myelofibrosis (MF) Symptoms and Quality of Life Measures with Splenomegaly Reduction in COMFORT-I: A Randomized, Double-Blind, Phase III Trial of the JAK1 and JAK2 Inhibitor Ruxolitinib Versus Placebo in Patients with MF
Mesa, R. A., Gotlib, J., Gupta, V., DiPersio, J. F., Catalano, J., Deininger, M. W., 鈥 Verstovsek, S. (2011). Associations Between Improvements in Myelofibrosis (MF) Symptoms and Quality of Life Measures with Splenomegaly Reduction in COMFORT-I: A Randomized, Double-Blind, Phase III Trial of the JAK1 and JAK2 Inhibitor Ruxolitinib Versus Placebo in Patients with MF. BLOOD, 118(21), 1642鈥43. -
A Novel Missense Mutation In An MDS Patient and Effects on TET2 mRNA Expression and Clinical Outcomes
Pollyea, D. A., Raval, A., Kusler, B., Gotlib, J. R., Alizadeh, A. A., & Mitchell, B. S. (2010). A Novel Missense Mutation In An MDS Patient and Effects on TET2 mRNA Expression and Clinical Outcomes. BLOOD, 116(21), 788. -
Longer-Term Follow up with TG101348 Therapy In Myelofibrosis Confirms Sustained Improvement In Splenomegaly,, Disease-Related Symptoms, and JAK2V617F Allele Burden
Pardanani, A., Gotlib, J. R., Jamieson, C., Cortes, J. E., Talpaz, M., Stone, R. M., 鈥 Tefferi, A. (2010). Longer-Term Follow up with TG101348 Therapy In Myelofibrosis Confirms Sustained Improvement In Splenomegaly,, Disease-Related Symptoms, and JAK2V617F Allele Burden. BLOOD, 116(21), 205鈥6. -
KIT Inhibitor Midostaurin Exhibits a High Rate of Clinically Meaningful and Durable Responses in Advanced Systemic Mastocytosis: Report of a Fully Accrued Phase II Trial
Gotlib, J., DeAngelo, D. J., George, T. I., Corless, C. L., Linder, A., Langford, C., 鈥 Graubert, T. (2010). KIT Inhibitor Midostaurin Exhibits a High Rate of Clinically Meaningful and Durable Responses in Advanced Systemic Mastocytosis: Report of a Fully Accrued Phase II Trial. BLOOD, 116(21), 144. -
Eosinophilic Disorders: Differential Diagnosis and Management
Gotlib, J. (2011). Eosinophilic Disorders: Differential Diagnosis and Management. MYELOPROLIFERATIVE NEOPLASMS- BIOLOGY AND THERAPY, 181鈥203. -
RAPID siRNA Screen for Identification of Therapeutic Gene Targets in Patients with Hematologic Malignancies
Tyner, J. W., Loriaux, M., Willis, S. G., Chang, B. H., Bicocca, V. T., Oh, S. T., 鈥 Druker, B. J. (2009). RAPID siRNA Screen for Identification of Therapeutic Gene Targets in Patients with Hematologic Malignancies. BLOOD. AMER SOC HEMATOLOGY. -
AML Patients with Monosomal Karyotype Are Characterized by Absence of NPM1 and FLT3 Mutations and Worse Clinical Outcome.
Seetharam, M., Weinberg, O. K., Ren, L., Ma, L., Seo, K., Zehnder, J. L., 鈥 Arber, D. A. (2009). AML Patients with Monosomal Karyotype Are Characterized by Absence of NPM1 and FLT3 Mutations and Worse Clinical Outcome. BLOOD, 114(22), 1035. -
A Phase I Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2V617F Allele Burden
Pardanani, A. D., Gotlib, J. R., Jamieson, C., Cortes, J., Talpaz, M., Stone, R., 鈥 Tefferi, A. (2009). A Phase I Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2V617F Allele Burden. BLOOD, 114(22), 314鈥15. -
Development of a Small-Molecule Inhibitor Screen to Rapidly Identify Key Signaling Pathways in Leukemogenesis
Tyner, J. W., Fletcher, L., Yang, W., Oh, S. T., Gotlib, J. R., Deininger, M. W. N., 鈥 Loriaux, M. (2009). Development of a Small-Molecule Inhibitor Screen to Rapidly Identify Key Signaling Pathways in Leukemogenesis. BLOOD. AMER SOC HEMATOLOGY. -
Small-Molecule Inhibitor Screen Rapidly Identifies Key Signaling Pathways in Leukemogenesis.
Tyner, J. W., Erickson, H., Oh, S., Gotlib, J. R., Deininger, M. W. N., Druker, B. J., & Loriaux, M. (2008). Small-Molecule Inhibitor Screen Rapidly Identifies Key Signaling Pathways in Leukemogenesis. BLOOD. AMER SOC HEMATOLOGY. -
RNAi Screening of the Tyrosine Kinome Identifies Therapeutic Targets in Leukemia Patients
Tyner, J. W., Loriaux, M., Willis, S. G., Chang, B., Bicocca, V. T., Oh, S., 鈥 Druker, B. J. (2008). RNAi Screening of the Tyrosine Kinome Identifies Therapeutic Targets in Leukemia Patients. BLOOD. AMER SOC HEMATOLOGY. -
A Phase I Study of TG101348, An Orally Bioavailable JAK2-Selective Inhibitor, in Patients with Myelofibrosis
Pardanani, A. D., Gotlib, J., Jamieson, C., Cortes, J., Talpaz, M., Stone, R. M., 鈥 Tefferi, A. (2008). A Phase I Study of TG101348, An Orally Bioavailable JAK2-Selective Inhibitor, in Patients with Myelofibrosis. BLOOD, 112(11), 43鈥44. -
Core-binding factor acute myeloid leukemia with t(8;21) Risk factors and a novel scoring system (I-CBFit)
Ustun, C., Morgan, E., Moodie, E. E. M., Pullarkat, S., Yeung, C., Broesby-Olsen, S., 鈥 Borthakur, G. (2018). Core-binding factor acute myeloid leukemia with t(8;21) Risk factors and a novel scoring system (I-CBFit). CANCER MEDICINE, 7(9), 4447鈥55. -
THE NUMBER AND TYPE OF MUTATIONS IN CANCER-LINKED GENES IS ASSOCIATED WITH OUTCOME OF SYSTEMIC MASTOCYTOSIS.
Munoz-Gonzalez, J. I., Jara-Acevedo, M., Alvarez-Twose, I., Merker, J. D., Teodosio, C., Henriques, A., 鈥 Garcia-Montero, A. C. (2018). THE NUMBER AND TYPE OF MUTATIONS IN CANCER-LINKED GENES IS ASSOCIATED WITH OUTCOME OF SYSTEMIC MASTOCYTOSIS. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 40, 102. -
PLATELET TRANSCRIPTOMIC SIGNATURES IN MYELOPROLIFERATIVE NEOPLASMS
Krishnan, A., Perkins, C., Gotlib, J., & Zehnder, J. (2018). PLATELET TRANSCRIPTOMIC SIGNATURES IN MYELOPROLIFERATIVE NEOPLASMS. AMERICAN JOURNAL OF HEMATOLOGY, 93(9), E34. -
Gender effect on phenotype and genotype in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis: results from the MYSEC project.
Barraco, D., Mora, B., Guglielmelli, P., Rumi, E., Maffioli, M., Rambaldi, A., 鈥 Passamonti, F. (2018). Gender effect on phenotype and genotype in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis: results from the MYSEC project. Blood Cancer Journal, 8(10), 89. -
Impact of somatic and germline mutations on the outcome of systemic mastocytosis.
Munoz-Gonzalez, J. I., Jara-Acevedo, M., Alvarez-Twose, I., Merker, J. D., Teodosio, C., Hou, Y., 鈥 Garcia-Montero, A. C. (2018). Impact of somatic and germline mutations on the outcome of systemic mastocytosis. Blood Advances, 2(21), 2814鈥28. -
The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives.
Valent, P., Oude Elberink, J. N., Gorska, A., Lange, M., Zanotti, R., van Anrooij, B., 鈥 Sperr, W. R. (2018). The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives. The Journal of Allergy and Clinical Immunology. In Practice. -
The new tool "KIT" in advanced systemic mastocytosis.
Shomali, W., & Gotlib, J. (2018). The new tool "KIT" in advanced systemic mastocytosis. Hematology. American Society of Hematology. Education Program, 2018(1), 127鈥36. -
Systemic Mastocytosis, Version 2.2019
Gotlib, J., Gerds, A. T., Bose, P., Castells, M. C., Deininger, M. W., Gojo, I., 鈥 Sundar, H. (2018). Systemic Mastocytosis, Version 2.2019. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 16(12), 1500鈥1537. -
Proposed Diagnostic Algorithm for Patients With Suspected Mast Cell Activation Syndrome.
Valent, P., Akin, C., Bonadonna, P., Hartmann, K., Brockow, K., Niedoszytko, M., 鈥 Metcalfe, D. D. (2019). Proposed Diagnostic Algorithm for Patients With Suspected Mast Cell Activation Syndrome. The Journal of Allergy and Clinical Immunology. In Practice. -
Revisiting diagnostic criteria for myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist.
Li, P., Shahmarvand, N., Lynch, D., Gotlib, J. R., Merker, J. D., Zehnder, J. L., 鈥 Ohgami, R. S. (2019). Revisiting diagnostic criteria for myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist. International Journal of Laboratory Hematology. -
Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells
Chae, H.-D., Murphy, L. C., Donato, M., Lee, A. G., Sweet-Cordero, E. A., Abidi, P., 鈥 Sakamoto, K. M. (2018). Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells. BLOOD. AMER SOC HEMATOLOGY. -
Solid Tumors in Post-Polycythemia Vera and Post-Essential Thrombocythemia Myelofibrosis: A Study on 2220 Patients
Mora, B., Rumi, E., Guglielmelli, P., Barraco, D., Maffioli, M., Rambaldi, A., 鈥 Passamonti, F. (2018). Solid Tumors in Post-Polycythemia Vera and Post-Essential Thrombocythemia Myelofibrosis: A Study on 2220 Patients. BLOOD, 132. -
Comprehensive Cytokine Profiling of Patients with Advanced Systemic Mastocytosis Treated with Midostaurin
Ediriwickrema, A., DeAngelo, D. J., George, T. I., Rosenberg-Hasson, Y., Perkins, C., Langford, C., & Gotlib, J. R. (2018). Comprehensive Cytokine Profiling of Patients with Advanced Systemic Mastocytosis Treated with Midostaurin. BLOOD, 132. -
Phase 2 Study of Ruxolitinib in Patients with Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia
Dao, K.-H., Collins, R. H., Cortes, J. E., Deininger, M. W., Druker, B. J., Gotlib, J. R., 鈥 Winton, E. F. (2018). Phase 2 Study of Ruxolitinib in Patients with Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia. BLOOD. AMER SOC HEMATOLOGY. -
Avapritinib, a Potent and Selective Inhibitor of KIT D816V, Improves Symptoms of Advanced Systemic Mastocytosis (AdvSM): Analyses of Patient Reported Outcomes (PROs) from the Phase 1 (EXPLORER) Study Using the (AdvSM) Symptom Assessment Form (AdvSM-SAF), a New PRO Questionnaire for (AdvSM)
Gotlib, J. R., Radia, D., DeAngelo, D. J., Bose, P., Drummond, M. W., Hexner, E. O., 鈥 Deininger, M. W. (2018). Avapritinib, a Potent and Selective Inhibitor of KIT D816V, Improves Symptoms of Advanced Systemic Mastocytosis (AdvSM): Analyses of Patient Reported Outcomes (PROs) from the Phase 1 (EXPLORER) Study Using the (AdvSM) Symptom Assessment Form (AdvSM-SAF), a New PRO Questionnaire for (AdvSM). BLOOD, 132. -
Interim Results from Fight-203, a Phase 2, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Pemigatinib (INCB054828) in Patients with Myeloid/Lymphoid Neoplasms with Rearrangement of Fibroblast Growth Factor Receptor 1 (FGFR1)
Verstovsek, S., Vannucchi, A. M., Rambaldi, A., Gotlib, J. R., Mead, A. J., Hochhaus, A., 鈥 Reiter, A. (2018). Interim Results from Fight-203, a Phase 2, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Pemigatinib (INCB054828) in Patients with Myeloid/Lymphoid Neoplasms with Rearrangement of Fibroblast Growth Factor Receptor 1 (FGFR1). BLOOD, 132. -
A phase 2 study of ruxolitinib in combination with azacitidine in patients with myelofibrosis
Masarova, L., Verstovsek, S., Hidalgo-Lopez, J. E., Pemmaraju, N., Bose, P., Estrov, Z., 鈥 Daver, N. (2018). A phase 2 study of ruxolitinib in combination with azacitidine in patients with myelofibrosis. BLOOD, 132(16), 1664鈥74. -
Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis
Menghrajani, K., Boonstra, P. S., Mercer, J. A., Perkins, C., Gowin, K. L., Weber, A. A., 鈥 Talpaz, M. (2019). Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis. LEUKEMIA & LYMPHOMA, 60(4), 1036鈥42. -
Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.
Valent, P., Akin, C., Arock, M., Bock, C., George, T. I., Galli, S. J., 鈥 Horny, H.-P. P. (2017). Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal. EBioMedicine, 26, 17鈥24. -
Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology.
Hartmann, K., Escribano, L., Grattan, C., Brockow, K., Carter, M. C., Alvarez-Twose, I., 鈥 Valent, P. (2016). Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. The Journal of Allergy and Clinical Immunology, 137(1), 35鈥45. -
Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens.
Shoura, M. J., Gabdank, I., Hansen, L., Merker, J., Gotlib, J., Levene, S. D., & Fire, A. Z. (2017). Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens. G3 (Bethesda, Md.), 7(10), 3295鈥3303. -
Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.
Mughal, T. I., Pemmaraju, N., Radich, J. P., Deininger, M. W., Kucine, N., Kiladjian, J.-J., 鈥 Van Etten, R. A. (2019). Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms. Hematological Oncology. -
Second primary malignancies in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 2233 patients.
Mora, B., Rumi, E., Guglielmelli, P., Barraco, D., Maffioli, M., Rambaldi, A., 鈥 Passamonti, F. (2019). Second primary malignancies in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 2233 patients. Cancer Medicine. -
Revisiting diagnostic criteria for myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist
Li, P., Shahmarvand, N., Lynch, D., Gotlib, J. R., Merker, J. D., Zehnder, J. L., 鈥 Ohgami, R. S. (2019). Revisiting diagnostic criteria for myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 41(3), 345鈥52. -
MYC regulates the HIF-2alpha stemness pathway via Nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells.
Das, B., Pal, B., Bhuyan, R., Li, H., Sarma, A., Gayan, S., 鈥 Felsher, D. W. (2019). MYC regulates the HIF-2alpha stemness pathway via Nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells. Cancer Research. -
Gender effect on phenotype and genotype in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis: results from the MYSEC project
Barraco, D., Mora, B., Guglielmelli, P., Rumi, E., Maffioli, M., Rambaldi, A., 鈥 Passamonti, F. (2018). Gender effect on phenotype and genotype in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis: results from the MYSEC project. BLOOD CANCER JOURNAL, 8. -
A phase 2 study of brentuximab vedotin in patients with CD30-positive advanced systemic mastocytosis.
Gotlib, J., Baird, J. H., George, T. I., Langford, C., Reyes, I., Abuel, J., 鈥 Verstovsek, S. (2019). A phase 2 study of brentuximab vedotin in patients with CD30-positive advanced systemic mastocytosis. Blood Advances, 3(15), 2264鈥71. -
Genomic landscape of Neutrophilic Leukemias of Ambiguous Diagnosis.
Zhang, H., Wilmot, B., Bottomly, D., Dao, K.-H. T., Stevens, E., Eide, C. A., 鈥 Tyner, J. W. (2019). Genomic landscape of Neutrophilic Leukemias of Ambiguous Diagnosis. Blood. -
TIM3 and Galectin-9 are Novel Therapeutic Targets for Mastocytosis
Williams, M., George, T., Tripp, S., Deininger, M., Gotlib, J., & Hartmann, K. (2019). TIM3 and Galectin-9 are Novel Therapeutic Targets for Mastocytosis. LABORATORY INVESTIGATION, 99. -
TIM3 and Galectin-9 are Novel Therapeutic Targets for Mastocytosis
Williams, M., George, T., Tripp, S., Deininger, M., Gotlib, J., & Hartmann, K. (2019). TIM3 and Galectin-9 are Novel Therapeutic Targets for Mastocytosis. MODERN PATHOLOGY, 32. -
World Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management.
Shomali, W., & Gotlib, J. (2019). World Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management. American Journal of Hematology. -
MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis.
Jawhar, M., Schwaab, J., 脕lvarez-Twose, I., Shoumariyeh, K., Naumann, N., L眉bke, J., 鈥 Reiter, A. (2019). MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, JCO1900640. -
Impact of bone marrow fibrosis grade in post-polycythemia vera and post-essential thrombocythemia myelofibrosis. A study of the MYSEC group.
Mora, B., Guglielmelli, P., Rumi, E., Maffioli, M., Barraco, D., Rambaldi, A., 鈥 Passamonti, F. (2019). Impact of bone marrow fibrosis grade in post-polycythemia vera and post-essential thrombocythemia myelofibrosis. A study of the MYSEC group. American Journal of Hematology. -
A Kindred with a 脽-Globin Base Substitution [脽89(F5)Ser?Arg (AGT>AGG); HBB: c.270T>G] Resulting in Hemoglobin Vanderbilt.
Shomali, W., Brar, R., Arekapudi, S. R., & Gotlib, J. R. (2019). A Kindred with a 脽-Globin Base Substitution [脽89(F5)Ser?Arg (AGT>AGG); HBB: c.270T>G] Resulting in Hemoglobin Vanderbilt. Hemoglobin, 1鈥4. -
International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study.
Sperr, W. R., Kundi, M., Alvarez-Twose, I., van Anrooij, B., Oude Elberink, J. N., Gorska, A., 鈥 Valent, P. (2019). International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study. The Lancet. Haematology. -
PRM-151 in Myelofibrosis: Efficacy and Safety in an Open Label Extension Study
Verstovsek, S., Hasserjian, R. P., Pozdnyakova, O., Veletic, I., Mesa, R. A., Foltz, L., 鈥 Gotlib, J. R. (2018). PRM-151 in Myelofibrosis: Efficacy and Safety in an Open Label Extension Study. BLOOD, 132. -
Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry.
Kluin-Nelemans, H. C., Reiter, A., Illerhaus, A., van Anrooij, B., Hartmann, K., Span, L. F., 鈥 Sperr, W. R. (2019). Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry. Leukemia. -
New developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019.
Arock, M., Sotlar, K., Gotlib, J., Sperr, W. R., Hartmann, K., Schwartz, L. B., 鈥 Valent, P. (2019). New developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019. Leukemia & Lymphoma, 1鈥9. -
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao, K.-H. T., Gotlib, J., Deininger, M. M., Oh, S. T., Cortes, J. E., Collins, R. H., 鈥 Tyner, J. W. (2019). Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, JCO1900895. -
New Developments in Diagnosis, Prognostication, and Treatment of Advanced Systemic Mastocytosis.
Reiter, A., George, T. I., & Gotlib, J. R. (2020). New Developments in Diagnosis, Prognostication, and Treatment of Advanced Systemic Mastocytosis. Blood. -
Clinical Features and Survival of Patients with Indolent Systemic Mastocytosis defined by the Updated WHO Classification.
Trizuljak, J., Sperr, W. R., Nekvindov谩, L., Oude Elberink, H., Gleixner, K. V., Gorska, A., 鈥 Valent, P. (2020). Clinical Features and Survival of Patients with Indolent Systemic Mastocytosis defined by the Updated WHO Classification. Allergy. -
Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis.
Ronner, L., Podoltsev, N., Gotlib, J., Heaney, M. L., Kuykendall, A. T., O'Connell, C., 鈥 Mascarenhas, J. (2020). Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis. Blood. -
MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis
Jawhar, M., Schwaab, J., Alvarez-Twose, I., Shoumariyeh, K., Naumann, N., Luebke, J., 鈥 Reiter, A. (2020). MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis. ONCOLOGY RESEARCH AND TREATMENT. KARGER. -
Non-hematologic diagnosis of systemic mastocytosis: Collaboration of radiology and pathology.
Ozturk, K., Cayci, Z., Gotlib, J., Akin, C., George, T. I., & Ustun, C. (2020). Non-hematologic diagnosis of systemic mastocytosis: Collaboration of radiology and pathology. Blood Reviews, 100693. -
Midostaurin improves quality of life and mediator-related symptoms in advanced systemic mastocytosis.
Hartmann, K., Gotlib, J., Akin, C., Hermine, O., Awan, F. T., Hexner, E., 鈥 Kluin-Nelemans, H. C. (2020). Midostaurin improves quality of life and mediator-related symptoms in advanced systemic mastocytosis. The Journal of Allergy and Clinical Immunology. -
Venetoclax and hypomethylating agent therapy in high risk myelodysplastic syndromes: a retrospective evaluation of a real-world experience.
Azizi, A., Ediriwickrema, A., Dutta, R., Patel, S. A., Shomali, W., Medeiros, B., 鈥 Zhang, T. (2020). Venetoclax and hypomethylating agent therapy in high risk myelodysplastic syndromes: a retrospective evaluation of a real-world experience. Leukemia & Lymphoma, 1鈥8. -
Risk and Management of Patients with Mastocytosis and MCAS in the SARS-CoV-2 (COVID-19) Pandemic: Expert Opinions.
Valent, P., Akin, C., Bonadonna, P., Brockow, K., Niedoszytko, M., Nedoszytko, B., 鈥 Hartmann, K. (2020). Risk and Management of Patients with Mastocytosis and MCAS in the SARS-CoV-2 (COVID-19) Pandemic: Expert Opinions. The Journal of Allergy and Clinical Immunology. -
Real-World Outcomes of Ruxolitinib Treatment for Polycythemia Vera.
Coltoff, A., Mesa, R., Gotlib, J., Shulman, J., Rampal, R. K., Siwoski, O., 鈥 Mascarenhas, J. (2020). Real-World Outcomes of Ruxolitinib Treatment for Polycythemia Vera. Clinical Lymphoma, Myeloma & Leukemia. -
Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts.
Valent, P., Akin, C., Hartmann, K., Nilsson, G., Reiter, A., Hermine, O., 鈥 Galli, S. J. (2020). Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts. Theranostics, 10(23), 10743鈥68. -
Core-binding factor acute myeloid leukemia with inv(16): Older age and high white blood cell count are risk factors for treatment failure.
Ustun, C., Morgan, E. A., Ritz, E. M., Vestergaard, H., Pullarkat, S., Kluin, P. M., 鈥 Marcucci, G. (2020). Core-binding factor acute myeloid leukemia with inv(16): Older age and high white blood cell count are risk factors for treatment failure. International Journal of Laboratory Hematology. -
Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.
Gerds, A. T., Gotlib, J., Bose, P., Deininger, M. W., Dunbar, A., Elshoury, A., 鈥 Sundar, H. (2020). Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN, 18(9), 1248鈥69. -
Dynamic and Time-To-Event Analyses Demonstrate Marked Reduction in Transfusion Requirements for Janus Kinase Inhibitor-Naive Myelofibrosis Patients Treated with Momelotinib Compared Head to Head with Ruxolitinib
McLornan, D., Mesa, R., Catalano, J., Cervantes, F., Devos, T., Egyed, M., 鈥 Kowalski, M. (2020). Dynamic and Time-To-Event Analyses Demonstrate Marked Reduction in Transfusion Requirements for Janus Kinase Inhibitor-Naive Myelofibrosis Patients Treated with Momelotinib Compared Head to Head with Ruxolitinib. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. -
Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Deininger, M. W., Shah, N. P., Altman, J. K., Berman, E., Bhatia, R., Bhatnagar, B., 鈥 Sundar, H. (2020). Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN, 18(10), 1385鈥1415. -
Practical Management of Adverse Events in Patients With Advanced Systemic Mastocytosis Receiving Midostaurin.
Gotlib, J., Kluin-Nelemans, H. C., Akin, C., Hartmann, K., Valent, P., & Reiter, A. (2020). Practical Management of Adverse Events in Patients With Advanced Systemic Mastocytosis Receiving Midostaurin. Expert Opinion on Biological Therapy. -
Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis
Kluin-Nelemans, H. C., Jawhar, M., Reiter, A., van Anrooij, B., Gotlib, J., Hartmann, K., 鈥 Sperr, W. R. (2021). Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis. THERANOSTICS, 11(1), 292鈥303. -
Sustained Complete Molecular Remission With Imatinib Monotherapy in a Child Presenting With Blast Phase FIP1L1-PDGFRA-Associated Myeloid Neoplasm With Eosinophilia.
Jain, J., Weinzierl, E. P., Saxe, D., Bergsagel, J., Gotlib, J., Reiter, A., & Raikar, S. S. (2020). Sustained Complete Molecular Remission With Imatinib Monotherapy in a Child Presenting With Blast Phase FIP1L1-PDGFRA-Associated Myeloid Neoplasm With Eosinophilia. HemaSphere, 4(6), e486. -
Scoring the risk of having systemic mastocytosis in adult patients with mastocytosis in the skin.
Fuchs, D., Kilbertus, A., Kofler, K., von Bubnoff, N., Shoumariyeh, K., Zanotti, R., 鈥 Valent, P. (2020). Scoring the risk of having systemic mastocytosis in adult patients with mastocytosis in the skin. The Journal of Allergy and Clinical Immunology. In Practice. -
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
Wernig, G. (2021). Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proceedings of the National Academy of Sciences, 118 (2)(Jan 2021). -
Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis.
Kluin-Nelemans, H. C., Jawhar, M., Reiter, A., van Anrooij, B., Gotlib, J., Hartmann, K., 鈥 Sperr, W. R. (2021). Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis. Theranostics, 11(1), 292鈥303. -
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
Cui, L., Moraga, I., Lerbs, T., Van Neste, C., Wilmes, S., Tsutsumi, N., 鈥 Wernig, G. (2021). Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proceedings of the National Academy of Sciences of the United States of America, 118(2). -
What your HalphaT says about you.
Gotlib, J. (2021). What your HalphaT says about you. Blood, 137(2), 151鈥53. -
Routine use of gemtuzumab ozogamicin in 7?+?3-based inductions for all 'non-adverse' risk AML.
Ladha, A., Hui, G., Cheung, E., Berube, C., Coutre, S. E., Gotlib, J., 鈥 Mannis, G. N. (2021). Routine use of gemtuzumab ozogamicin in 7?+?3-based inductions for all 'non-adverse' risk AML. Leukemia & Lymphoma, 1鈥6. -
Proposed global prognostic score for systemic mastocytosis: a retrospective prognostic modelling study.
Mu帽oz-Gonz谩lez, J. I., 脕lvarez-Twose, I., Jara-Acevedo, M., Zanotti, R., Perkins, C., Jawhar, M., 鈥 Orfao, A. (2021). Proposed global prognostic score for systemic mastocytosis: a retrospective prognostic modelling study. The Lancet. Haematology. -
Clinical Impact of Skin Lesions in Mastocytosis: A Multicenter Study of the European Competence Network on Mastocytosis (ECNM).
Aberer, E., Sperr, W. R., Bretterklieber, A., Avian, A., Hadzijusufovic, E., Kluin-Nelemans, H. C., 鈥 Valent, P. (2021). Clinical Impact of Skin Lesions in Mastocytosis: A Multicenter Study of the European Competence Network on Mastocytosis (ECNM). The Journal of Investigative Dermatology. -
Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference.
Gotlib, J., George, T., Carter, M. C., Austen, K. F., Bochner, B., Dwyer, D., 鈥 Akin, C. (2021). Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference. The Journal of Allergy and Clinical Immunology. -
Response Criteria in Advanced Systemic Mastocytosis: Evolution in the Era of KIT Inhibitors.
Shomali, W., & Gotlib, J. (2021). Response Criteria in Advanced Systemic Mastocytosis: Evolution in the Era of KIT Inhibitors. International Journal of Molecular Sciences, 22(6). -
COVID-19 vaccination in mastocytosis: recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM).
Bonadonna, P., Brockow, K., Niedoszytko, M., Elberink, H. O., Akin, C., Nedoszytko, B., 鈥 Valent, P. (2021). COVID-19 vaccination in mastocytosis: recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM). The Journal of Allergy and Clinical Immunology. In Practice. -
Avapritinib induces responses in patients with advanced systemic mastocytosis, regardless of prior midostaurin therapy
Radia, D., Drummond, M. W., Gotlib, J., George, T. I., Quiery, A. T., Winton, E., 鈥 DeAngelo, D. J. (2021). Avapritinib induces responses in patients with advanced systemic mastocytosis, regardless of prior midostaurin therapy. BRITISH JOURNAL OF HAEMATOLOGY. WILEY. -
A Phase 1/2 Study of INCB000928 as Monotherapy or in Combination with Ruxolitinib in Patients with Anemia Due to Myelofibrosis (INCB 00928-104)
Oh, S., Kiladjian, J.-J., Palandri, F., Gotlib, J., Mohan, S., Ali, H., 鈥 Verstovsek, S. (2021). A Phase 1/2 Study of INCB000928 as Monotherapy or in Combination with Ruxolitinib in Patients with Anemia Due to Myelofibrosis (INCB 00928-104). BRITISH JOURNAL OF HAEMATOLOGY. WILEY. -
Secondary cytogenetic abnormalities in core-binding factor AML harboring inv(16) vs t(8;21).
Han, S. Y., Mrozek, K., Voutsinas, J., Wu, Q., Morgan, E. A., Vestergaard, H., 鈥 Yeung, C. C. (2021). Secondary cytogenetic abnormalities in core-binding factor AML harboring inv(16) vs t(8;21). Blood Advances, 5(10), 2481鈥2489. -
Results from PIONEER: a randomized, double-blind, placebo-controlled, phase 2 study of avapritinib in patients with indolent systemic mastocytosis
Radia, D. H., Sabato, V., Castells, M., Akin, C., Elberink, H. O., Tashi, T., 鈥 Gotlib, J. (2021). Results from PIONEER: a randomized, double-blind, placebo-controlled, phase 2 study of avapritinib in patients with indolent systemic mastocytosis. BRITISH JOURNAL OF HAEMATOLOGY. WILEY. -
Psychometric evaluation of the Advanced Systemic Mastocytosis Symptom Assessment Form (AdvSM-SAF).
Taylor, F., Li, X., Yip, C., Padilla, B., Mar, B., Green, T., 鈥 Gotlib, J. (2021). Psychometric evaluation of the Advanced Systemic Mastocytosis Symptom Assessment Form (AdvSM-SAF). Leukemia Research, 108, 106606. -
Ruxolitinib discontinuation in polycythemia vera: Patient characteristics, outcomes, and salvage strategies from a large multi-institutional database.
Tremblay, D., Ronner, L., Podoltsev, N., Gotlib, J., Heaney, M., Kuykendall, A., 鈥 Mascarenhas, J. (2021). Ruxolitinib discontinuation in polycythemia vera: Patient characteristics, outcomes, and salvage strategies from a large multi-institutional database. Leukemia Research, 109, 106629. -
Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 (JAK2) V617F and KIT proto-oncogene, receptor tyrosine kinase (KIT) D816V mutations.
Naumann, N., Lubke, J., Shomali, W., Reiter, L., Horny, H.-P., Jawhar, M., 鈥 Schwaab, J. (2021). Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 (JAK2) V617F and KIT proto-oncogene, receptor tyrosine kinase (KIT) D816V mutations. British Journal of Haematology. -
Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review.
Gulen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., 鈥 Valent, P. (2021). Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review. The Journal of Allergy and Clinical Immunology. In Practice. -
Diagnosis and management of neutrophilic myeloid neoplasms.
Schwede, M., Gotlib, J., & Shomali, W. (2021). Diagnosis and management of neutrophilic myeloid neoplasms. Clinical Advances in Hematology & Oncology : H&O, 19(7), 450鈥459. -
Diagnosis and Management of Neutrophilic Myeloid Neoplasms
Schwede, M., Gotlib, J., & Shomali, W. (2021). Diagnosis and Management of Neutrophilic Myeloid Neoplasms. CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 19(7), 450鈥459. -
PATHFINDER: Interim analysis of avapritinib (ava) in patients (pts) with advanced systemic mastocytosis (AdvSM).
DeAngelo, D. J., Reiter, A., Radia, D., Deininger, M. W., George, T. I., Panse, J., 鈥 Gotlib, J. (2021). PATHFINDER: Interim analysis of avapritinib (ava) in patients (pts) with advanced systemic mastocytosis (AdvSM). CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
A Phase 1/2 Study of INCB000928 as Monotherapy or in Combination with Ruxolitinib in Patients with Anemia Due to Myelofibrosis (INCB 00928-104).
Oh, S. T., Kiladjian, J.-J., Palandri, F., Gotlib, J. R., Mohan, S., Ali, H., 鈥 Verstovsek, S. (2021). A Phase 1/2 Study of INCB000928 as Monotherapy or in Combination with Ruxolitinib in Patients with Anemia Due to Myelofibrosis (INCB 00928-104). CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
Current and future status of JAK inhibitors
McLornan, D. P., Pope, J. E., Gotlib, J., & Harrison, C. N. (2021). Current and future status of JAK inhibitors. LANCET, 398(10302), 803鈥816. -
A novel activating JAK1 mutation in chronic eosinophilic leukemia.
Shomali, W., Damnernsawad, A., Theparee, T., Sampson, D., Morrow, Q., Yang, F., 鈥 Gotlib, J. R. (2021). A novel activating JAK1 mutation in chronic eosinophilic leukemia. Blood Advances. -
Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance.
Chen, J. A., Hou, Y., Roskin, K. M., Arber, D. A., Bangs, C. D., Baughn, L. B., 鈥 Gotlib, J. (2021). Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance. Blood Advances, 5(17), 3492鈥3496. -
Efficacy and Safety of <= 200 mg Avapritinib in Patients with Advanced Systemic Mastocytosis: Pooled Results from the Phase 1 EXPLORER and Interim Phase 2 PATHFINDER Studies
Radia, D., DeAngelo, D., Deininger, M. W., Reiter, A., Sen, J., Lin, H. M., 鈥 Gotlib, J. (2021). Efficacy and Safety of <= 200 mg Avapritinib in Patients with Advanced Systemic Mastocytosis: Pooled Results from the Phase 1 EXPLORER and Interim Phase 2 PATHFINDER Studies. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. -
Myeloid/Lymphoid Neoplasms with Eosinophilia and TKI Fusion Genes: Treatment
Reiter, A., Cross, N. C. P., & Gotlib, J. (2021). Myeloid/Lymphoid Neoplasms with Eosinophilia and TKI Fusion Genes: Treatment. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. -
Chronic Eosinophilic Leukemia: Diagnosis and Therapy
Gotlib, J., Shomali, W., & Reiter, A. (2021). Chronic Eosinophilic Leukemia: Diagnosis and Therapy. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. CIG MEDIA GROUP, LP. -
World Health Organization-defined eosinophilic disorders: 2021 update on diagnosis, risk stratification, and management.
Shomali, W., & Gotlib, J. (2021). World Health Organization-defined eosinophilic disorders: 2021 update on diagnosis, risk stratification, and management. American Journal of Hematology. -
Refined diagnostic criteria for bone marrow mastocytosis: a proposal of the European competence network on mastocytosis.
Zanotti, R., Bonifacio, M., Lucchini, G., Sperr, W. R., Scaffidi, L., van Anrooij, B., 鈥 Valent, P. (2021). Refined diagnostic criteria for bone marrow mastocytosis: a proposal of the European competence network on mastocytosis. Leukemia. -
Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms
Shen, Z., Du, W., Perkins, C., Fechter, L., Natu, V., Maecker, H., 鈥 Krishnan, A. (2021). Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. CELL REPORTS MEDICINE, 2(10). -
Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms.
Shen, Z., Du, W., Perkins, C., Fechter, L., Natu, V., Maecker, H., 鈥 Krishnan, A. (2021). Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. Cell Reports. Medicine, 2(10), 100425. -
Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal
Valent, P., Akin, C., Hartmann, K., Alvarez-Twose, I., Brockow, K., Hermine, O., 鈥 Metcalfe, D. D. (2021). Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal. HEMASPHERE, 5(11). -
Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial.
DeAngelo, D. J., Radia, D. H., George, T. I., Robinson, W. A., Quiery, A. T., Drummond, M. W., 鈥 Gotlib, J. (2021). Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial. Nature Medicine. -
Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial.
Gotlib, J., Reiter, A., Radia, D. H., Deininger, M. W., George, T. I., Panse, J., 鈥 DeAngelo, D. J. (2021). Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial. Nature Medicine. -
Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal.
Valent, P., Akin, C., Hartmann, K., Alvarez-Twose, I., Brockow, K., Hermine, O., 鈥 Metcalfe, D. D. (2021). Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal. HemaSphere, 5(11), e646. -
Comparison of the Transcriptomic Signatures in Pediatric and Adult CML.
Youn, M., Smith, S. M., Lee, A. G., Chae, H.-D., Spiteri, E., Erdmann, J., 鈥 Sakamoto, K. M. (1800). Comparison of the Transcriptomic Signatures in Pediatric and Adult CML. Cancers, 13(24). -
Superior Efficacy of Midostaurin Over Cladribine in Advanced Systemic Mastocytosis: A Registry-Based Analysis.
Lubke, J., Schwaab, J., Naumann, N., Horny, H.-P., WeiSS, C., Metzgeroth, G., 鈥 Reiter, A. (2022). Superior Efficacy of Midostaurin Over Cladribine in Advanced Systemic Mastocytosis: A Registry-Based Analysis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, JCO2101849.
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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
Clinical Trials
Clinical trials are 糖心传媒 studies that evaluate a new medical approach, device, drug, or other treatment. As a 糖心传媒 patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis
- An Extension Study for Subjects Who Are Deriving Benefit With Idelalisib (GS-1101; CAL-101) Following Completion of a Prior Idelalisib Study
- Evaluating the Safety of Long Term Dosing of Romiplostim (Formerly AMG 531) in Thrombocytopenic Subjects With Myelodysplastic Syndromes (MDS)
- Safety Study of CAT-8015 Immunooxin in Patients With HCL With Advance Disease
- Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma
- A Phase 2 Study With IPI-926 in Patients With Myelofibrosis
- Integrated Whole-Genome Analysis of Hematologic Disorders
- Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Practice Locations
Hematologic Cancer Program Palo Alto, CA
Palo Alto, CAHematologic Cancer Program
875 Blake Wilbur Dr
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
糖心传媒, 糖心传媒 Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by 糖心传媒, 糖心传媒 Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of 糖心传媒, 糖心传媒 Tri- Valley, or Stanford Medicine Partners. 糖心传媒, 糖心传媒 Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Review Summary
Dr. Gotlib is known for his thoroughness and attentiveness to patient concerns. He is regarded as knowledgeable and an excellent communicator. Many appreciate that he listens carefully, provides clear guidance, and ensures all questions are answered. Patients express feeling cared for and comfortable under his care, valuing his expertise and the time he takes to understand their individual needs.
The summary was created by AI, based on recent patient reviews. Learn more
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Referring Physicians
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