Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study

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Abstract

Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment.Sixty men who had received =?3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent (T2) and 8 weeks later (T3). The acceptability of CCT was also assessed.Feasibility:A priori feasibility thresholds were partially met (i.e., randomization rate >?50%, retention rate >?70% excluding CCT drop-outs, but

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