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Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma

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Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma LEUKEMIA Marafioti, T., Pozzobon, M., Hansmann, M. L., Gaulard, P., Barth, T. F., Copie-Bergman, C., Roberton, H., Ventura, R., Martin-Subero, J. I., Gascoyne, R. D., Pileri, S. A., Siebert, R., Hsi, E. D., Natkunam, Y., Moller, P., Mason, D. Y. 2005; 19 (5): 856-861

Abstract

Two microarray studies of mediastinal B cell lymphoma have shown that this disease has a distinct gene expression profile, and also that this is closest to the pattern seen in classical Hodgkin's disease. We reported previously an immunohistologic study in which the loss of intracellular B cell-associated signaling molecules in Reed-Sternberg cells was demonstrated, and in this study we have investigated the expression of the same components in more than 60 mediastinal B cell lymphomas. We report that these signaling molecules are frequently present, and in particular that Syk, BLNK and PLC-gamma2 (absent from Reed-Sternberg cells) are present in the majority of mediastinal B cell lymphomas. The overall pattern of B cell signaling molecules in this disease is therefore closer to that of diffuse large B cell lymphoma than to Hodgkin's disease, and is consistent with a common cell of origin as an explanation of the similar gene expression profiles.

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