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Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx.

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Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx. Head & neck Shiao, J. C., Mohamed, A. S., Messer, J. A., Hutcheson, K. A., Johnson, J. M., Enderling, H., Kamal, M., Warren, B. W., Pham, B., Morrison, W. H., Zafereo, M. E., Hessel, A. C., Lai, S. Y., Kies, M. S., Ferrarotto, R., Garden, A. S., Schomer, D. F., Gunn, G. B., Phan, J., Frank, S. J., Beadle, B. M., Weber, R. S., Lewin, J. S., Rosenthal, D. I., Fuller, C. D. 2017

Abstract

The purpose of this study was to determine the impact of CT-determined pretreatment primary tumor volume on survival and disease control in T4a laryngeal squamous cell carcinoma (SCC).We retrospectively reviewed 124 patients with T4a laryngeal cancer from 2000-2011. Tumor volume measurements were collected and correlated with outcomes.Five-year overall survival (OS) for patients with tumor volume =21 cm(3) treated with larynx preservation (n = 26 of 41) was significantly inferior compared to <21 cm(3) (42% vs 64%, respectively; P = .003). Five-year OS for patients with tumor volumes =21 cm(3) in the cohort treated with total laryngectomy followed by radiotherapy (RT; n = 42 of 83) was not statistically significant when compared to <21 cm(3) (50% vs 63%, respectively; P = .058). On multivariate analysis, tumor volume =21 cm(3) was a significant independent correlate of worse disease-specific survival (DSS; P = .004), event-free survival (P = .005), recurrence-free survival (RFS; P = .04), noncancer cause-specific survival (P = .02), and OS (P = .0002).Pretreatment CT-based tumor volume is an independent prognostic factor of outcomes in T4a laryngeal cancer.

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