Factors influencing the participation of gastroenterologists and hepatologists in clinical ÌÇÐÄ´«Ã½

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Abstract

Although clinical ÌÇÐÄ´«Ã½ is integral to the advancement of medical knowledge, physicians face a variety of obstacles to their participation as investigators in clinical trials. We examined factors that influence the participation of gastroenterologists and hepatologists in clinical ÌÇÐÄ´«Ã½.We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical ÌÇÐÄ´«Ã½. We compared the survey responses by specialty and level of clinical trial experience.A majority of the respondents (71.6%) reported involvement in ÌÇÐÄ´«Ã½ activities. Factors most influential in clinical trial participation included funding and compensation (88.3%) and intellectual pursuit (87.8%). Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical ÌÇÐÄ´«Ã½ers. These barriers included uncompensated ÌÇÐÄ´«Ã½ costs and lack of specialized support. Industry marketing was a greater influence among respondents with less trial experience, compared to those with extensive experience (15.7% vs 1.6%; P < .01). Hepatologists and respondents with extensive clinical trial experience tended to be more interested in phase 1 and 2 studies, whereas gastroenterologists and less experienced investigators were more interested in phase 4 studies.This study suggests that the greatest barrier to participation in clinical ÌÇÐÄ´«Ã½ is lack of adequate resources. Respondents also favored industry-sponsored ÌÇÐÄ´«Ã½ with less complex trial protocols and studies of relatively short duration.

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