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High-Density Lipoprotein NanoparticleÌýImaging in AtheroscleroticÌýVascularÌýDisease.

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High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease. JACC. Basic to translational science Leeper, N. J., Park, S. M., Smith, B. R. 2017; 2 (1): 98-100

Abstract

Nanoparticles promise to advance the field of cardiovascular theranostics. However, their sustained and targeted delivery remains an important obstacle. The body synthesizes some "natural" nanoparticles, including high-density lipoprotein (HDL), which may home to the atherosclerotic plaque and promote cholesterol efflux. In a recent article published in JACC: Cardiovascular Imaging, investigators generated modified, radiolabeled HDL nanoparticles and confirmed they accumulated in atherosclerotic lesions from several different species. These approaches hold promise for the noninvasive diagnosis of vulnerable plaque and in the stratification of patients in whom HDL-mimetic therapy may have a clinical benefit.

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