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PolyQ Disease: Too Many Qs, Too Much Function?
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PolyQ Disease: Too Many Qs, Too Much Function? NEURON Kratter, I. H., Finkbeiner, S. 2010; 67 (6): 897–99Abstract
The nature of the gain-of-function toxicity found in polyglutamine (polyQ) diseases has been the subject of considerable debate. In this issue of Neuron, Duvick et al. and Nedelsky et al. show that, in two of these diseases, pathology is mediated by normal protein activity.
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