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Multimodality treatment including whole pleura radiation therapy for DICER1-associated pediatric pleuropulmonary blastoma.
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Multimodality treatment including whole pleura radiation therapy for DICER1-associated pediatric pleuropulmonary blastoma. Pediatric blood & cancer Hui, C., Shin, D. H., Wakeling, A., Donaldson, S. S., Hazard, F. K., Rangaswami, A., Hiniker, S. M. 2021: e29004Abstract
Limited data are available regarding radiation therapy in pediatric pleuropulmonary blastoma (PPB). We report the case of a 3-year-old girl with type II PPB successfully treated with trimodality therapy including multiagent chemotherapy, resection, and whole pleura radiation therapy. While longer follow-up is required to confirm ultimate local tumor control and long-term post-treatment sequelae, currently 3.5years following therapy, she is well, without recurrent disease or observable toxicity. The goal of this report is to add our experience to the literature regarding PPB, its management, and treatment, as prospective randomized controlled trials are not feasible due to the rarity of this disease.
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