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Abnormal shear stress and residence time are associated with proximal coronary atheroma in the presence of myocardial bridging.

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Abnormal shear stress and residence time are associated with proximal coronary atheroma in the presence of myocardial bridging. International journal of cardiology Yong, A. S., Pargaonkar, V. S., Wong, C. C., Javadzdegan, A., Yamada, R., Tanaka, S., Kimura, T., Rogers, I. S., Sen, I., Kritharides, L., Schnittger, I., Tremmel, J. A. 2021

Abstract

BACKGROUND: Atheromatous plaques tend to form in the coronary segments proximal to a myocardial bridge (MB), but the mechanism of this occurrence remains unclear. This study evaluates the relationship between blood flow perturbations and plaque formation in patients with an MB.METHODS AND RESULTS: A total of 92 patients with an MB in the mid left anterior descending artery (LAD) and 20 patients without an MB were included. Coronary angiography, intravascular ultrasound, and coronary physiology measurements were performed. A moving-boundary computational fluid dynamics algorithm was used to derive wall shear stress (WSS) and peak residence time (PRT). Patients with an MB had lower WSS (0.46?±?0.21 vs. 0.96?±?0.33?Pa, p?

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