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A Consideration for Surgical Management in Select T4b Oral Cavity Squamous Cell Carcinoma.

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A Consideration for Surgical Management in Select T4b Oral Cavity Squamous Cell Carcinoma. The Annals of otology, rhinology, and laryngology Chen, M. M., Chang, C. M., Dermody, S., Rosko, A. J., Mierzwa, M. L., Swiecicki, P. L., Spector, M. E., Worden, F. P., Prince, M. E., Chinn, S. B. 2022; 131 (6): 609-616

Abstract

The role of surgery for conventionally "unresectable" (cT4b) oral cavity squamous cell carcinoma is unclear. We analyzed factors associated with overall survival in cT4b relative to cT4a oral cavity squamous cell carcinoma.We identified 6830 cT4a and 522 cT4b oral cavity squamous cell carcinoma chemoradiation or surgery?+?adjuvant therapy patients in the National Cancer Data Base from 2004 to 2016. The main outcome was overall survival. Statistical analysis was performed using chi-squared tests, univariable and multivariable regression analysis.The cT4b group had a higher rate of positive margins (30.4% vs 21.3%, P?=?.009) and downstaging (41.2% vs 13.1%; P?

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