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Understanding and Investigating Sex-Based Differences in Heart Transplantation: A Call to Action.
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Understanding and Investigating Sex-Based Differences in Heart Transplantation: A Call to Action. JACC. Heart failure DeFilippis, E. M., Nikolova, A., Holzhauser, L., Khush, K. K. 2023Abstract
Women represent only about 25% of heart transplant recipients annually. Although the number of women living with advanced heart failure remains unknown, epidemiologic ÌÇÐÄ´«Ã½ suggests that more women should be receiving advanced heart failure therapies. Sex differences in risk factors, presentation, response to pharmacotherapy, and outcomes in heart failure have been well described. Yet, less is known about sex differences in heart transplant candidate selection, waitlist management, donor selection, perioperative considerations, and post-transplant management and outcomes. The purpose of this review was to summarize the existing published reports related to sex differences in heart transplantation, highlighting areas in which sex-based considerations are well described and supported by available evidence, and emphasizing topics that require further study.
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