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Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations.
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Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations. Stem cell ÌÇÐÄ´«Ã½ Zhang, M., Venkateshappa, R., Li, A., Fowler, M. B., Telli, M. L., Wu, J. C. 2023; 73: 103246Abstract
We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer.
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