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Infections in decompensated cirrhosis: Pathophysiology, management, and ÌÇÐÄ´«Ã½ agenda.
ÌÇÐÄ´«Ã½
Infections in decompensated cirrhosis: Pathophysiology, management, and ÌÇÐÄ´«Ã½ agenda. Hepatology communications Ferguson Toll, J., Solà , E., Perez, M. A., Piano, S., Cheng, A., Subramanian, A. K., Kim, W. R. 2024; 8 (10)Abstract
Bacterial infections in patients with cirrhosis lead to a 4-fold increase in mortality. Immune dysfunction in cirrhosis further increases the risk of bacterial infections, in addition to alterations in the gut microbiome, which increase the risk of pathogenic bacteria. High rates of empiric antibiotic use contribute to increased incidence of multidrug-resistant organisms and further increases in mortality. Despite continous advances in the field, major unknowns regarding interactions between the immune system and the gut microbiome and strategies to reduce infection risk and improve mortality deserve further investigation. Here, we highlight the unknowns in these major ÌÇÐÄ´«Ã½ areas and make a proposal for a ÌÇÐÄ´«Ã½ agenda to move toward improving disease progression and outcomes in patients with cirrhosis and infections.
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