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Embracing the Future of Clinical Trials in Radiotherapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.
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Embracing the Future of Clinical Trials in Radiotherapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions. International journal of radiation oncology, biology, physics Xiao, Y., Benedict, S., Cui, Y., Glide-Hurst, C., Graves, S., Jia, X., Kry, S. F., Li, H., Lin, L., Matuszak, M., Newpower, M., Paganetti, H., Qi, X. S., Roncali, E., Rong, Y., Sgouros, G., Simone, C. B., Sunderland, J. J., Taylor, P. A., Tchelebi, L., Weldon, M., Zou, J. W., Wuthrick, E. J., Machtay, M., Le, Q. T., Buchsbaum, J. C. 2025Abstract
This white paper examines the potential of pioneering technologies and artificial intelligence (AI)-driven solutions in advancing clinical trials involving radiotherapy. As the field of radiotherapy evolves, the integration of cutting-edge approaches such as radiopharmaceutical dosimetry, FLASH radiotherapy, image-guided radiation therapy (IGRT), and AI promises to improve treatment planning, patient care, and outcomes. Additionally, recent advancements in quantum science, linear energy transfer/relative biological effect (LET/RBE), and the combination of radiotherapy and immunotherapy create new avenues for innovation in clinical trials. The paper aims to provide an overview of these emerging technologies and discuss their challenges and opportunities in shaping the future of radiation oncology clinical trials. By synthesizing knowledge from experts across various disciplines, this white paper aims to present a foundation for the successful integration of these innovations into radiotherapy ÌÇÐÄ´«Ã½ and practice, ultimately enhancing patient outcomes and revolutionizing cancer care.
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