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Epigenetic enhancement of adoptive T cell immunotherapy.
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Epigenetic enhancement of adoptive T cell immunotherapy. Cancer cell Dai, Z., Smith, M. 2025; 43 (3): 340-342Abstract
Isshiki et al. and Porazzi et al. report that inhibiting enhancer of zeste homolog 1 (EZH1) and EZH2 enhances chimeric antigen receptor (CAR)/T cell receptor (TCR)-based therapies by reprogramming tumors to be more immunogenic and improving T cell phenotype and demonstrate the efficacy of this combination in preclinical models across hematologic and solid cancers. Clinical trials are ongoing to evaluate its safety and therapeutic potential.
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