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Macrowire-only direct aspiration first-pass technique for endovascular mechanical thrombectomy: Multicenter technical series using the 0.035 aristotle Colossus wire.

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Macrowire-only direct aspiration first-pass technique for endovascular mechanical thrombectomy: Multicenter technical series using the 0.035 aristotle Colossus wire. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences Ares, W., Tonetti, D., Koneru, M., Dalkilic, A., Salah, W., Brinjikji, W., Rajjoub, K., Raz, E., Khawaja, A., Southwood, C., Dalyai, R., Birnbaum, L., Chowdhry, S., Do, H., Joyce, E., Calnan, D., Malek, A., Grandhi, R. 2025: 15910199251343117

Abstract

BackgroundLarger "macrowires" may facilitate microcatheter-free delivery of large-bore aspiration catheters (ACs) for intracranial endovascular mechanical thrombectomy. We examined the safety and efficacy of the Aristotle Colossus Guidewire for this use.MethodsIn this retrospective analysis of prospective data from 12 institutions, we identified anterior circulation endovascular mechanical thrombectomy cases involving the Aristotle Colossus guidewire over a 12-month period. The primary efficacy endpoint was successful delivery of the AC to the site without the use of adjunct devices. Multivariable logistic regression was performed with clinically relevant covariables.ResultsIn 122 patients (median age 74 years (interquartile range (IQR) 63-82)), most intracranial occlusions were in the M1 segment of the middle cerebral artery (95/122, 78.0%). The primary endpoint of microcatheter-free AC delivery was met in 87.7% (107/122) of patients; 93/122 (76.2%) patients underwent microcatheter-free delivery with successful reperfusion via contact aspiration (modified thrombolysis in cerebral infarction grade=2B). The median number of passes was 1 (IQR 1-2). Multivariable regression demonstrated that severe internal carotid artery tortuosity or cervical loop presence (odds ratio (OR): 0.09, 95% confidence interval (CI): 0.01-0.54, p=0.01) and presence of intracranial atherosclerotic disease (OR: 0.15, 95% CI: 0.03-0.83, p=0.03) were significantly associated with lower odds of successful AC delivery over the guidewire. Intraprocedural vasospasm occurred in 4.9% (6/122) of cases; there were no reports of vessel dissection or perforation.ConclusionsWe demonstrate the favorable performance of the Aristotle Colossus guidewire for anterior circulation ischemic stroke intervention. The macrowire appears to safely facilitate navigation of the neurovasculature by large-bore ACs without the need for microcatheter and/or stentriever.

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