Evaluation of Patients With Non-obstructive Coronary Arteries
Trial ID or NCT#
NCT00823563
Status
RECRUITING
Purpose
Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment. When these patients undergo a comprehensive evaluation at the time of invasive coronary angiography, occult coronary abnormalities are frequently found. We hope to learn the overall prevalence and presentation of these occult coronary abnormalities and its long term outcome in this patient population.
Official Title
Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease
Eligibility Criteria
Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
- 1. Patient referred for elective coronary angiography because of a reasonable clinical suspicion of coronary ischemia.2. Presence of angina or an anginal equivalent (including chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath brought on by physical exertion, emotional stress, or certain times of day/month).
Exclusion Criteria:
- 1. Asymptomatic (such as a pre-op cath)2. Status-post heart transplant3. Age \<184. Renal insufficiency (creatinine \>1.5)5. Presence of an acute coronary syndrome (STEMI or NSTEMI), Tako-tsubo, an abnormal ejection fraction (EF\<55%), cardiogenic shock, or recent VT/VF6. Presence of another likely explanation of chest pain, such as pulmonary hypertension or aortic stenosis7. History of adverse reaction to any of the medications being used (acetylcholine, nitroglycerin, adenosine, or heparin)8. Currently taking vasoactive medication (such as nitroglycerin)9. Inability to provide an informed consent, including an inability to speak, read, or understand English, Spanish, Chinese, Farsi, Japanese, Korean, Russian, or Vietnamese10. A hearing impairment that won't allow for a typical verbal conversation or a visual impairment that won't allow for reading of the written consent11. Participation in another study (with the exception of the Stanford Gene-PAD study)12. A potentially vulnerable subject (including minors, pregnant women, economically and educationally disadvantaged, decisionally impaired, and homeless people)
Investigator(s)
Jennifer Tremmel
Interventional cardiologist,
Cardiologist
Susan P. and Riley P. Bechtel Medical Director and Associate Professor of Medicine (Cardiovascular Medicine)
Marcia L. Stefanick, Ph.D.
Contact us to find out if this trial is right for you.
Contact
Homa Tavana
650-721-5540
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