Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging
Trial ID or NCT#
Status
NOT RECRUITING
Purpose
The proposed clinical trial is relevant to public health because it is expected to expand the differential diagnosis and provide an evidence--based therapy for the large population of patients with angina in the absence of obstructive CAD who currently remain undiagnosed and untreated. It, therefore, upholds an important part of the mission of the The National Heart, Lung, and Blood Institute (NHLBI), which is to promote the treatment of heart disease and enhance the health of all individuals so that they can live longer and more fulfilling lives.
Official Title
Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging
Eligibility Criteria
- 1. Asymptomatic2. Status--post heart transplant3. Presence of another likely explanation of chest pain, such as pulmonary hypertension, hypertrophic obstructive cardiomyopathy, or aortic stenosis4. Presence of an acute coronary syndrome (unstable angina, NSTEMI, or STEMI), Tako--tsubo, or cardiogenic shock5. An abnormal left ventricular ejection fraction (EF\<55%)6. History of a severe adverse reaction to beta blockers or calcium channel blockers (prior minor intolerance or ineffectiveness not exclusion)7. Use of existing medication that has an unsafe drug--drug interaction with beta blockers or calcium channel blockers8. Refusal to take beta blockers or calcium channel blockers9. Resting systolic blood pressure \<100 mmHg or heart rate \<50 beats per minute10. Inability to provide an informed consent, including an inability to speak, read, or understand English or Spanish11. A hearing impairment that won't allow for a typical verbal conversation or a visual impairment that won't allow for reading of the written consent12. A potentially vulnerable subject (including pregnant women, prisoners, economically and educationally disadvantaged, decisionally impaired, and institutionalized individuals)
Investigator(s)
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Contact
Jennifer A Tremmel, MD
650-723-0180
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