Study of Bimonthly VEGF Trap-Eye Compared to As-needed Administration or Other Therapy for Exudative Age-Related Macular Degeneration
Trial ID or NCT#
Status
NOT RECRUITING
Purpose
Over the last several years, the standard of care for wet macular degeneration has become treatment with intravitreal injections of ranibizumab (Lucentis, Genentech), administered as frequently as every 4 weeks. In contrast, clinical trials of a soluble VEGF receptor, Aflibercept/VEGF Trap-Eye (Eylea, Regeneron Pharmaceuticals) have demonstrated maintained anatomic and visual improvement with many fewer injections (typically monthly injections for 3 months, followed by every-other-month injections, and as few as 5 injections a year). The purpose of this study is to determine whether patients who have switched from ranibizumab to VEGF Trap-Eye have comparable results.
Official Title
Bimonthly VEGF Trap-Eye Compared to As-needed Administration or Standard Therapy for Exudative Age-Related Macular Degeneration
Eligibility Criteria
- 1. Patients older than the age of 50 determined by a retinal physician at the Byers Eye Institute at Stanford to have exudative AMD requiring treatment.2. Patients with an established diagnosis of exudative AMD who have been maintained on a regimen of intravitreal ranibizumab injections.3. Postmenopausal or negative pregnancy test4. Patients with an established diagnois of exidative AMD who have been switched from intravitreal ranibizumab to intravitreal VEGF Trap-EYE.
- 1. Patients with any previous or concurrent history of treatment of other retinal diseases with pharmacologic agents other than ranibizumab, including verteporfin photodynamic therapy, bevacizumab, triamcinolone, or dexamethasone.2. Patients with prior history of vitrectomy surgery in the study eye.3. Patients enrolled in any previous or current clinical trial or study of any medication for AMD or any other retinal vascular disease, including diabetic retinopathy or retinal vein occlusion.4. Ocular media opacity precluding proper retinal imaging5. Inadequate pupillary dilation to achieve proper retinal imaging6. Concurrent use of systemic anti-VEGF agents7. CNV due to other causes, including histoplasmosis, uveitis, trauma, or myopia8. Active or recent (\< 4 weeks) or recurrent inflammation in the eye9. Current vitreous hemorrhage in the study eye limiting visualization of the fundus10. Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis11. Untreated glaucoma with IOP \> 25 in the eye12. Other ocular diseases that can compromise the visual acuity of the study eye such as amblyopia and anterior ischemic optic neuropathy13. Pregnancy or lactation14. History of other disease, exam finding, or clinical laboratory that contraindicates the use the drug15. Current treatment for active systemic infection16. Evidence of significant uncontrolled concomitant diseases such as cardiovascular disease, pulmonary, renal, hepatic, endocrine, or GI disorders17. History of recurrent significant infections or bacterial infections18. Inability to comply with study or follow-up procedure
Investigator(s)
Contact us to find out if this trial is right for you.
Contact
Theodore Leng, MD
650-723-6995
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