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Medications that can treat Alzheimer's disease

Many people believe that Alzheimer’s disease (AD) can't be treated. The truth is that medications are available that may help treat symptoms. Although these drugs don’t work for everyone, they offer some hope for the more than 6 million people who have Alzheimer’s Disease.

Treatment for mild to moderate Alzheimer’s disease

There are three FDA-approved drugs available to treat symptoms due to mild to moderate Alzheimer’s Disease. While the drugs may delay decline in memory and reduce confusion, they are not curative and are unable to stop the disease from worsening over time. In fact, patients and families often notice no change in memory after taking these medicines.

Three drugs used to treat AD are all in one family, called cholinesterase inhibitors, which boost brain levels of acetylcholine:

• Galantamine (Razadyne®)
• Rivastigmine (Exelon®)
• Donepezil (Aricept®)

Certain side effects may prevent people from using medication for AD. Donepezil, galantamine, and rivastigmine can cause nausea and vomiting.

The FDA has approved two drugs that may slow the progression of Alzheimer’s Disease and are only indicated for people with mild disease:

• Lecanemab (Lequembi®)
• Donanemab (Kisunla®)

These drugs target removal of brain amyloid, one of the proteins that build up in brain in people with Alzheimer’s Disease. Before starting these drugs, your doctor will need to confirm the presence of amyloid in your brain. Your doctor will order either an amyloid PET scan or spinal tap.

The effects of Lecanemab and Donanemab in people with early Alzheimer’s Disease are still being studied.

Learn more about important safety, eligibility, and cost information for Lecanemab.

Treatment for moderate to severe Alzheimer’s disease

Memantine (Namenda®) is the only drug approved by the FDA to treat symptoms due to moderate to severe stages of AD. Memantine works by reducing the amount of the chemical glutamate in the brain.Ìý It can be taken alone or with a cholinesterase inhibitor. Side effects of memantine may include confusion, dizziness and headache.